Module 6 Problem_ Sex Determination

docx

School

Arizona State University *

*We aren’t endorsed by this school

Course

MISC

Subject

Biology

Date

Dec 6, 2023

Type

docx

Pages

2

Uploaded by DeanCloverWasp28

Report
Leo Majeed Bio 351- Nov 22, 2023 Module 6 Problems - Sex Determination 1) Protein Produced: ● DMRT1 (Doublesex and Mab-3-related transcription factor 1) encodes a protein that belongs to the DMRT (Doublesex and Mab-3-related transcription factor) family. DMRT proteins are involved in sex determination and differentiation. Reference: Raymond, C. S., & Murphy, M. W. (2014). Oviparous vertebrates: model systems for studying sex determination and differentiation. Current topics in developmental biology, 109, 459-485. 2) Chromosome Location: ● The DMRT1 gene is located on chromosome 9 in mice. Reference: Hacker, A., Capel, B., Goodfellow, P., & Lovell-Badge, R. (1995). Expression of Sry, the mouse sex determining gene. Development, 121(6), 1603- 1614. 3) Pathway and Role in Sex Determination: ● DMRT1 is involved in the sex determination pathway and plays a crucial role in the development of male reproductive organs. It is expressed in the developing gonads and is essential for testis development in mammals. DMRT1 promotes the differentiation of the bipotential gonad into a testis
by suppressing ovarian development. Reference: Matson, C. K., & Zarkower, D. (2012). Sex and the singular DM domain: insights into sexual regulation, evolution and plasticity. Nature Reviews Genetics, 13(3), 163-174. 4) Mutations in Humans and Phenotype: ● Mutations in the DMRT1 gene in humans are associated with disorders of sex development (DSD). DSD refers to conditions where the development of chromosomal, gonadal, or anatomical sex is atypical. Mutations in DMRT1 can lead to a range of phenotypes, including male-to-female sex reversal, ambiguous genitalia, and gonadal dysgenesis. Reference: Bashamboo, A., Ferraz-de-Souza, B., Lourenço, D., Lin, L., Sebire, N. J., Montjean, D., ... & Achermann, J. C. (2016). Human male infertility associated with mutations in NR5A1 encoding steroidogenic factor 1. American Journal of Human Genetics, 92(6), 1074-1081.
Your preview ends here
Eager to read complete document? Join bartleby learn and gain access to the full version
  • Access to all documents
  • Unlimited textbook solutions
  • 24/7 expert homework help

Related Documents

nmontegrande_Module06AssessmentWorksheet_03112022.docx
Unit 2 Lab - Protists, porifera, cnidaria.docx
Staph Meeting 13.docx
C105 Pathways Project Peer Feedback Form 2023.docx
Bread_Mold_Experiment.pdf
Exercise 4 Worksheet.pdf
Mid-term Exam 1, Spring 2022.pdf
Germs Everywhere Part 4_2020.docx.pdf
Module 3 Post-Lab Workbook - Intro to Science.pdf
BIO 210 Quiz Immune and Respiratory Systems.docx
Rewrite exam.docx
Lab4W23SimluatingEvolution-2.pdf
Recommended textbooks for you
Text book image
Biology: The Unity and Diversity of Life (MindTap...
Biology
ISBN:9781305073951
Author:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Publisher:Cengage Learning
Text book image
Biology Today and Tomorrow without Physiology (Mi...
Biology
ISBN:9781305117396
Author:Cecie Starr, Christine Evers, Lisa Starr
Publisher:Cengage Learning
Text book image
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
Text book image
Biology: The Dynamic Science (MindTap Course List)
Biology
ISBN:9781305389892
Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher:Cengage Learning
Text book image
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
Text book image
Biology: The Unity and Diversity of Life (MindTap...
Biology
ISBN:9781337408332
Author:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Publisher:Cengage Learning
SEE MORE TEXTBOOKS
Recommended textbooks for you
Text book image
Biology: The Unity and Diversity of Life (MindTap...
Biology
ISBN:9781305073951
Author:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Publisher:Cengage Learning
Text book image
Biology Today and Tomorrow without Physiology (Mi...
Biology
ISBN:9781305117396
Author:Cecie Starr, Christine Evers, Lisa Starr
Publisher:Cengage Learning
Text book image
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
Text book image
Biology: The Dynamic Science (MindTap Course List)
Biology
ISBN:9781305389892
Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher:Cengage Learning
Text book image
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
Text book image
Biology: The Unity and Diversity of Life (MindTap...
Biology
ISBN:9781337408332
Author:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Publisher:Cengage Learning
SEE MORE TEXTBOOKS