Kami Export - LS7C Week 4B Pre-Class Reading Guide (1)

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LS7C

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Biology

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Feb 20, 2024

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Name _____________________________________________ LS7C Week 4B Pre-Class Reading Guide Fill out this worksheet as you complete your pre-class assignments. Bring your completed worksheet to class to use as a reference for in-class activities. After completing your pre-class assignments, you should be able to: • Describe the structure and function of a neuromuscular junction • Identify cellular, molecular, and protein components involved in muscle contraction and explain their role • Relate the structure of skeletal muscle to its function in generating a contractile force • Describe the cross-bridge cycle in a skeletal muscle 1. Describe the general organization of skeletal muscle tissue. On the diagram below label and define the terms muscle fiber, myofibril, and muscle bundle. Which of these represents an individual cell? Where would you find an individual sarcomere? Where would you find mitochondria? You may find it helpful to refer to Figure 36.3 in your textbook. 2. Illustrate a skeletal muscle sarcomere distinguishing between thin and thick filaments. On your diagram, indicate where myosin cross-bridges form with actin. How does the relative length of the sarcomere change when the muscle is undergoing relaxation versus contraction?

3. The diagram below shows a neuromuscular junction, the synapse that forms between a motor neuron and a muscle cell. Using your knew knowledge of muscles and your previous knowledge of synapses, provide an explanation for what is happening at each of the eight labeled steps in the diagram. You may find it helpful to refer to Figure 36.8 in your textbook, and to review Figure 35.10 from the week 2 assignments. 1. 2. 3. 4. 5. 6. 7. 8.

4. Refer to Figures 36.5 and 36.6 in your textbook. Draw a diagram of a muscle sarcomere in a relaxed state and a contracted state. Label the myosin thick filaments and actin thin filaments. 5. Explain how the proteins troponin and tropomyosin are involved in skeletal muscle contraction. You may find it helpful to refer to Figure 36.4 in your textbook. 6. The diagram below shows the skeletal muscle cross-bridge cycle. Write a brief explanation for what is happening at each of the four steps shown in the cycle. You may find it helpful to refer to Figure 36.7 in your textbook.

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