WEEK 1 LAB

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School

Chamberlain University College of Nursing *

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Course

255

Subject

Biology

Date

Feb 20, 2024

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docx

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5

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Week 1 Blood Learning Objectives: Identify the cellular components of blood and state their functions. Explain the role of the white blood cells in protecting the body from disease. Analyze complete blood counts. Learn how to use an automatic hematology analyzer and how to prepare a peripheral smear. Name the 4 major blood types in the ABO system. Explain the principles of blood typing using Eldon cards. Describe Rh incompatibility and hemolytic disease of the newborn. Introduction: The body is a complex multicellular organism that comprises trillions of cells working together as tissues, organs, and systems. These cells require a continuous supply of oxygen and nutrients in order to function. They also need an efficient and fast means of delivery of these substances as well as a means of removing waste byproducts. Blood is composed of 2 components: blood plasma and the formed elements. In the first lab simulation, you will generate complete blood counts and prepare blood smears of control and patient samples to diagnose various blood disorders in three patients. Dive into the inner workings of the different blood components with immersive 3D animations, where you will get acquainted with the morphology and function of red blood cells, white blood cells, and platelets. In the second lab you will learn the basics of antibodies. Even though antibodies are proteins that protect us from harmful intruders, they can sometimes cause problems. You will learn about antibody-antigen interaction and the mechanism that lies behind Rh incompatibility. You will discover what antigens and antibodies have to do with blood type, and why mixing certain different blood types together can cause problems. In this simulation, you will examine blood samples from a mother and her unborn child, to determine whether or not they are compatible. Assignment: Part 1: Complete Labster “Hematology: Introduction to Blood” As you complete the lab, have the lab report ready to record data. The theory section of the lab is a useful resource. Part 2: Complete Labster “Antibodies: Why are some blood types incompatible?” As you complete the lab, have the lab report ready to record data. The theory section of the lab is a useful resource.
Part 3: Complete the Lab report. Blood Lab Report Answer the following questions: Part 1 Lab questions: 1. Identify the WBCs: (1 point each) a. MONOCYTE b.
NEUTROPHIL 2. Record the Data: (3 points) Patient CBC abnormality Peripheral smear result Patient 1 WBC, PLT Intracellular parasite Patient 2 Hb, HCT, MCV, MCH Abnormal RBC shape Patient 3 NONE Fuzzy RBC cell membrane 3. What is the importance of a complete blood count? (1 point) A complete blood count measures the overall health of a person by measuring the blood cells (Redd & White) and platelets. It will show any defects in the blood to determine if there is any blood disorders. 4. What information does a peripheral smear add to the results of a complete blood count? (1 point) A peripheral smear can show changed in your blood cell and platelet shape and size to detect blood disorders. 5. Identify the diagnosis of the 3 patients in the Part 1 Labster lab as determined by their CBC and Peripheral Smear results. (3 points) Patient 1: Malaria Patient 2: Sickle Cell Anemia
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Patient 3: Hemophilia Part 2 Lab questions: 6. When is Rh incompatibility an issue for a pregnant woman and her baby? (1 point) Rh incompatibility is an issue when the mother is negative and the baby is positive. 7. What do the antibodies in the “Anti-D” test circle detect? (1 point) The antibodies in the “Anti-D” test circle will detect if the Rh status is negative or positive. 8. What is the cause of blood agglutination on the Eldon test cards? (1 point) Blood agglutination on the Eldon test cards are due to the Eldon test cards having A, B, and Rh antigens on it. 9. Why can agglutination be lethal for a patient when it occurs during a blood transfusion? (1 point) Agglutination can be lethal for a patient because it can clog the blood vessels and stop the flow of blood through the body. 10. Why is blood type O neg called the “universal donor”? (1 point) Type O neg blood is called the “universal donor” because it has no antigens and therefore will not activate an immune response. Grading Rubric for Lab Report Activity   Deliverable   Points   Part 1 Complete Labster “Hematology: Introduction to Blood” 10 Part 2 Complete Labster “Antibodies: Why are some blood types incompatible?” 10 Part 3 Complete lab report 10 Total   Complete all lab activities   30 Abbreviations CBC: complete blood count WBC: white blood cell