Chapter SRP, Problem 16P

Interpretation Introduction

Interpretation:

The structures for the compound diphenhydramine and for the intermediates $\text{A}$ and $\text{B}$ are to be given, and a possible mechanism is to be given for the last step of the synthesis.

Concept Introduction:

Diphenhydramine is an antihistamine which is chiefly used for treating allergies. It contains two phenyl groups. It is also known as Benadryl.

An organic aromatic compound which contains the benzene ring with a substituent formyl group is known as benzaldehyde.

When the reaction takes place between organo-halogen and magnesium in the presence of nitrogen in environment, this type of reaction is called Grignard reaction.

The formula proposed for the Grignard reagent is $\text{RMgX}$, in which $\text{R}$ represents the alkyl or aryl group and $\text{X}$ represents the halogen.