EBK ORGANIC CHEMISTRY
EBK ORGANIC CHEMISTRY
12th Edition
ISBN: 9781119233664
Author: Snyder
Publisher: VST
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Chapter SRP, Problem 15P
Interpretation Introduction

Interpretation:

The structures of ethinamate and intermediates A and B are to be provided.

Concept Introduction:

Ethinamate is a carbamate derivative, which is used to treat insomnia. They are sedative hypnotic drugs.

Ethinamate are carbamate esters, their depressant effects are slower than other sedative drugs like barbiturates.

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2. Please consider the two all 'cis' isomers of trimethylcyclohexane drawn below. Draw the two chair conformers of each stereoisomer below (1 and 2) and calculate their torsional interaction energies in order to identify the lower energy conformer for each stereoisomer. Based on your calculations, state which of the two stereoisomers 1 and 2 is less stable and which is more stable. [1,3-diaxial CH3 CH3 = 3.7kcal/mol; 1,3-diaxial CH3 H = 0.88kcal/mol; cis-1,2 (axial:equatorial) CH3 CH3 = 0.88kcal/mol; trans-1,2-diequatorial CH3 CH3 = 0.88kcal/mol) all-cis-1,2,3- 1 all-cis-1,2,4- 2
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EBK ORGANIC CHEMISTRY

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