Essentials of Genetics (9th Edition) - Standalone book
9th Edition
ISBN: 9780134047799
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
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Textbook Question
Chapter CHST4, Problem 1RQ
What is pharmacogenomics, and how does it differ from pharmacogenetics?
Expert Solution & Answer
Summary Introduction
To review:
The difference between pharmacogenomics and pharmacogenetics.
Introduction:
The field of personalized medicine has led to the prediction for the therapists to determine the probable cause and its correct therapeutics measures. The advanced techniques associated with the DNA (Deoxyribose nucleic acid) sequencing, cataloging the DNA sequence, and fingerprinting led the revolutionary changes in the field of genomics and the personalized medicine. Genomics is basically the branch of the biology that focuses on the structure, evolution, function, and the mapping procedures of the genomes of the organism.
Explanation of Solution
The difference between pharmacogenomics and pharmacogenetics is given in the table below:
| Pharmacogenomics | Pharmacogenetics |
| Pharmacogenomics refers to the study that deals that how the personal genetic makeup of an individual is useful in determining the response of the body to the drugs. | Pharmacogenetics is the study that deals with the variations in the genes of an organism for determining the response against the drugs. |
| Patient-drug interactions are also involved in the pharmacogenomics. It is concerned with the development of the therapies for compensating the genetic differences. | Pharmacogenetics also involved the variations in the metabolisms of the medications given to the adults, children, and many people having a different type of medical conditions. |
| The area of pharmacogenomics deals with the effectiveness of the single drug for the wide assessment expression of the genome in the presence of the particular drug. | This area of pharmacogenetics deals with the related effect of the single drug on patient variabilities and various genomes. |
Conclusion
Thus, it can be concluded that the pharmacogenomics tells that how the entire genome can influence the drug response. The pharmacogenetics tells that how a single gene can influence the response for a particular drug.
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Case Study—Ella
Ella has a family history of diabetes. She wants to follow a healthful eating pattern that can lower her risk for developing this condition. Her dietitian recommends a goal of 450 to 600 kcal per meal and advises Ella to follow the Acceptable Macronutrient Distribution Range (AMDR) for carbohydrates and the Dietary Guidelines for Americans 2015-2020, which recommend limiting added sugar. She also recommends that Ella choose whole grains rather than processed grains. Ella decides to pack a lunch to take to work every day. This morning she’s making a sandwich for her lunch.
Categories of Sandwich Options (Top of the screen)
Breads
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Cheeses
Vegetables
Proteins
Specific food items to select
White Bread 6-inches
Honey Mustard
Provolone
LettuceTomatoBell Peppers
Turkey
Part A - Reading Nutrition Facts Panels for Total Kilocalories
How many total kilocalories are in Ella’s sandwich exactl ______kcal ?
Part B - Reading Nutrition Facts Panels for…
C
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Biopharmaceutics and Pharmacokinetics:Two-Compartment Model Instant Absorption Questions
SHOW ALL WORK, including equation used, variables used and each step to your solution, report your regression lines and axes names (with units if appropriate) :Calculate a-q
a) B1,
b) B2,
c) hybrid rate constant (1)
d) hybrid rate constant (2)
e) t1/2,dist
f) t1/2,elim
g) k10
h) k12
i) k21
j) initial concentration (C0)
k) central compartment volume (V1)
l) steady-state volume (Vss)
m) clearance (CL) AUC (0→10 min) using trapezoidal rule
n) AUC (20→30 min) using trapezoidal rule
o) AUCtail (AUC360→∞)
p) total AUC (using short cut method)
q) volume from AUC (VAUC)
Chapter CHST4 Solutions
Essentials of Genetics (9th Edition) - Standalone book
Ch. CHST4 - What is pharmacogenomics, and how does it differ...Ch. CHST4 - Describe how the drug Herceptin works. What types...Ch. CHST4 - Prob. 3RQCh. CHST4 - Prob. 4RQCh. CHST4 - What types of genetic tests are currently...Ch. CHST4 - Give two examples of how genomic studies have...Ch. CHST4 - Why is it necessary to examine gene-expression...Ch. CHST4 - Prob. 8RQCh. CHST4 - In this chapter, we present three case studies...Ch. CHST4 - What are the biggest challenges that must be...
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