Essential Cell Biology
Essential Cell Biology
4th Edition
ISBN: 9780815344544
Author: Keith Roberts, Karen Hopkin, Alexander D Johnson, Martin Raff, Dennis Bray, Bruce Alberts, Julian Lewis, Peter Walter
Publisher: TAYLOR
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Chapter 9, Problem 19Q
Summary Introduction

To explain: If all germ-line mutations that arise were preserved in descendants; how many cell generations must have elapsed since the days of Adam and Eve for 1 difference per 1000 nucleotides to have accumulated in modern humans.

Introduction:

The accuracy in replication of DNA is the most fundamental aspect of living system. Proof reading mechanism and DNA repair mechanism have a very significant role in minimizing errors between generations. A single base substitution can also result in significant impact on protein production. It may create a devastating genetic disorder, a beneficial adaptation, or might have a null effect. Every closely related species would share almost similar nucleotide sequences; they might be distinguished by the change in a single nucleotide sequence.

Summary Introduction

To explain:  If it is assumed that each human generation corresponds on average to 200 cell-division cycles in the germ-cell lineage and allowing 30 years per human generation, how many years ago would this ancestral couple have lived.

Introduction:

The accuracy in replication of DNA is the most fundamental aspect of living system. Proof reading mechanism and DNA repair mechanism have a very significant role in minimizing errors between generations. A single base substitution can also result in significant impact on protein production. It may create a devastating genetic disorder, a beneficial adaptation, or might have a null effect. Every closely related species would share almost similar nucleotide sequences; they might be distinguished by the change in a single nucleotide sequence.

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