Concepts of Genetics (11th Edition)
11th Edition
ISBN: 9780321948915
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
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Chapter 9, Problem 18PDQ
Researchers examined a family with an interesting distribution of Leigh syndrome symptoms. In this disorder, individuals may show a progressive loss of motor function (ataxia, A) with peripheral neuropathy (PN, meaning impairment of the peripheral nerves). A mitochondrial DNA (mtDNA) mutation that reduces ATPase activity was identified in various tissues of affected individuals. The accompanying table summarizes the presence of symptoms in an extended family.
- (a) Develop a pedigree that summarizes the information presented in the table.
- (b) Provide an explanation for the pattern of inheritance of the disease. What term describes this pattern?
- (c) How can some individuals in the same family show such variation in symptoms? What term, as related to organelle heredity, describes such variation?
- (d) In what way does a condition caused by mtDNA differ in expression and transmission from a mutation that causes albinism?
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Below is a pedigree of a human genetic disease in which solid color indicates affected individuals. Assume that the disease is caused by a gene that can have the alleles A or a.
a) Based on this pedigree, what is the most likely mode of inheritance?
b) What is/are the possible genotype/s of person 1?
c) What is/are the possible genotype (s) of person 4 ?
Explain your answers.
3) Achondroplasia is a common form of hereditary dwarfism that causes
very short limbs, stubby hands, and an enlarged forehead. Below are three
pedigrees depicting families with this specific type of dwarfism.
A. What is the most likely mode of inheritance?
a) Which of the four modes of inheritance are consistent with the disease shown in this human pedigrees below? (List the compatible mode or modes) Give an answer for a, b and c
b) If the parents in pedigree c have 2 other children, what is the probability that they will carry the disease?
Chapter 9 Solutions
Concepts of Genetics (11th Edition)
Ch. 9 - Chlamydomonas, a eukaryoric green alga, may be...Ch. 9 - In aerobically cultured yeast, a petite mutant is...Ch. 9 - DNA in human mitochondria encodes 22 different...Ch. 9 - Prob. 4NSTCh. 9 - In 2000, Rocco Baldelli was a first-round draft...Ch. 9 - In 2000, Rocco Baldelli was a first-round draft...Ch. 9 - Prob. 3CSCh. 9 - HOW DO WE KNOW? In this chapter, we focused on...Ch. 9 - Review the Chapter Concepts list on page 196. The...Ch. 9 - Streptomycin resistance in Chlamydomonas may...
Ch. 9 - A plant may have green, white, or green-and-white...Ch. 9 - In diploid yeast strains, sporulation and...Ch. 9 - Predict the results of a cross between ascospores...Ch. 9 - In Lymnaea, what results would you expect in a...Ch. 9 - In a cross of Lymnaea, the snail contributing the...Ch. 9 - In Drosophila subobscura, the presence of a...Ch. 9 - A male mouse from a true-breeding strain of...Ch. 9 - Consider the case where a mutation occurs that...Ch. 9 - What is the endosymbiotic theory, and why is this...Ch. 9 - In an earlier Problems and Discussion section (see...Ch. 9 - The specification of the anteriorposterior axis in...Ch. 9 - The maternal-effect mutation bicoid (bcd) is...Ch. 9 - (a) In humans the mitochondrial genome encodes a...Ch. 9 - Mutations in mitochondrial DNA appear to be...Ch. 9 - Researchers examined a family with an interesting...Ch. 9 - Payne, B. A. et al. (2013) present evidence that a...
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