Biological Science (6th Edition)
Biological Science (6th Edition)
6th Edition
ISBN: 9780321976499
Author: Scott Freeman, Kim Quillin, Lizabeth Allison, Michael Black, Emily Taylor, Greg Podgorski, Jeff Carmichael
Publisher: PEARSON
Question
Book Icon
Chapter 9, Problem 15PIAT
Summary Introduction

To review:

The effect of DNP (2,4-dinitrophenol) on lowering the weight gain by comparing the treated and control group of mice.

Introduction:

The DNP is a drug which dissipates the proton gradient across the mitochondrial membrane, which collapses the proton-motive force (PMF). The PMF is used for the generation of ATP (adenosine triphosphate). The production of ROS can be reduced using drugs that allow protons to freely pass through the inner membrane. The effect of DNP on the life span of mice is shown in the graph below. Each point represents the death of a single mouse.

Biological Science (6th Edition), Chapter 9, Problem 15PIAT

In this case, in addition to an increased life span, mice treated with low concentrations of DNP also showed a significantly lower weight gain compared to the control group despite no difference in the amount or type of food ingested.

Blurred answer
Students have asked these similar questions
If using animals in medical experiments could save human lives, is it ethical to do so? In your answer, apply at least one ethical theory in support of your position.
You aim to test the hypothesis that the Tbx4 and Tbx5 genes inhibit each other's expression during limb development. With access to chicken embryos and viruses capable of overexpressing Tbx4 and Tbx5, describe an experiment to investigate whether these genes suppress each other's expression in the limb buds. What results would you expect if they do repress each other? What results would you expect if they do not repress each other?
You decide to delete Fgf4 and Fgf8 specifically in the limb bud. Explain why you would not knock out these genes in the entire embryo instead.
Knowledge Booster
Background pattern image
Similar questions
SEE MORE QUESTIONS
Recommended textbooks for you
Text book image
Curren'S Math For Meds: Dosages & Sol
Nursing
ISBN:9781305143531
Author:CURREN
Publisher:Cengage
Text book image
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
Text book image
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
Text book image
Case Studies In Health Information Management
Biology
ISBN:9781337676908
Author:SCHNERING
Publisher:Cengage
Text book image
Biomedical Instrumentation Systems
Chemistry
ISBN:9781133478294
Author:Chatterjee
Publisher:Cengage
Text book image
Basic Clinical Laboratory Techniques 6E
Biology
ISBN:9781133893943
Author:ESTRIDGE
Publisher:Cengage