Chapter 9, Problem 13PIAT

Summary Introduction

To review:

From the given graph and study, the investigators determined that a low concentration of DNP increased the average life span from 719 days (Control) to 770 days (DNP). If the U.S. population has an average life span of 79 years, then how many years would be added if the same percentage increase were observed.

Introduction:

The 2,4-dinitrophenol (DNP) is used for the mice for reducing the production of reactive oxygen species (ROS), which allows the free passage of the protons across the inner mitochondrial membrane. The rate of survival is increased in the DNP treated mice as the oxidative damage caused by the ROS is decreased by the drug. The effect of a drug called DNP on the life span of mice is shown in the graph below. Each point represents the death of a single mouse.