Anatomy & Physiology
1st Edition
ISBN: 9781938168130
Author: Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher: OpenStax College
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Textbook Question
Chapter 8, Problem 23RQ
The ischial spine is found between which of the following stnic titres?
- inferior pubic ramus and ischial ramus
- pectineal line and arcuate line
- lesser sciatic notch and greater sciatic notch
- anterior superior iliac spine and posterior superior iliac spine
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 8 Solutions
Anatomy & Physiology
Ch. 8 - Watch this video...Ch. 8 - Visit this site...Ch. 8 - Watch this video...Ch. 8 - Watch this video...Ch. 8 - Watch this video...Ch. 8 - Visit this site...Ch. 8 - Use this tutorial...Ch. 8 - View this link...Ch. 8 - Watch this animation...Ch. 8 - Which part of the clavicle articulates with the...
Ch. 8 - A shoulder separation results from injury to the...Ch. 8 - Which feature lies between the spine and superior...Ch. 8 - What structure is an extension of the spine of the...Ch. 8 - Name the short, hook-like bony process of the...Ch. 8 - How many bones are there in the upper limbs...Ch. 8 - Which bony landmark is located on the lateral side...Ch. 8 - Which region of the humerus articulates with the...Ch. 8 - Which is the lateral-most carpal bone of the...Ch. 8 - The radius bone ________. is found on the medial...Ch. 8 - How many bones fuse in adulthood to form the hip...Ch. 8 - Which component forms the superior part of the hip...Ch. 8 - Which of the following supports body weight when...Ch. 8 - The ischial spine is found between which of the...Ch. 8 - The pelvis ________. has a subpubic angle that is...Ch. 8 - Which bony landmark of the femur selves as a site...Ch. 8 - What structure contributes to the knee joint?...Ch. 8 - Which tarsal bone articulates with the tibia and...Ch. 8 - What is the total number of bones found in the...Ch. 8 - The tibia ________. has an expanded distal end...Ch. 8 - Which event takes place during the seventh week of...Ch. 8 - During endochondral ossification of a long bone,...Ch. 8 - The clavicle ________. develops via inhamembianous...Ch. 8 - Describe the shape and palpable line formed by the...Ch. 8 - Discuss two possible injuries of the pectoral...Ch. 8 - Your friend runs out of gas and you have to help...Ch. 8 - Name the bones in the wrist and hand, and describe...Ch. 8 - Describe the articulations and ligaments that...Ch. 8 - Discuss the ways in which the female pelvis is...Ch. 8 - Define the regions of the lower limb, name the...Ch. 8 - The talus bone of the foot receives the weight of...Ch. 8 - How can a radiograph of a childs femur be used to...Ch. 8 - How does the development of the clavicle differ...
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