FUNDAMENTALS OF BIOCHEM.-NEXTGEN ACCESS
5th Edition
ISBN: 9781119661450
Author: Voet
Publisher: WILEY
expand_more
expand_more
format_list_bulleted
Concept explainers
Question
Chapter 7, Problem 4E
Summary Introduction
To calculate: The p50 value for hemoglobin if Y = 0.82 when pO2 = 25 torr.
Concept introduction: The fractional saturation is the partial fulfillment of the allosteric sites of the protein by the ligand. The ligand in hemoglobin is oxygen. The fractional saturation (Y) is the fraction at which the protein molecules are saturated with the ligand. At Y50, half the protein molecules are bound to ligand and half to proteins, and ligands are free, thus the equilibrium is achieved. The concentration of gas is mentioned as partial pressure. Torr is the unit of measure for pressure.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Obtain the sequence for the 5-HT receptor HTR1A and generate a hydropathy plot usingthe ExPASY tool ProtScale, the appropriate window, and the Kyte-Doolittle weightingalgorithm. How many transmembrane domains are present in this receptor?
From the reaction data below, determine whether the reaction is first order or second order and calculate the rate constant.
Time (s)
0
Reactant (mM)
5.4
1
4.6
2
3.9
3
3.2
4
2.7
5
2.3
Only a plot of In[reactant] versus t gives a straight line, so the reaction is
first order
. The negative of the slope, k, is
0.171
Hair grows at a rate of about 20 cm/yr. All this growth is concentrated at the base of the hair fiber, where a-keratin filaments are
synthesized inside living epidermal cells and assembled into ropelike structures.
Two-chan
14
Protofilament
20-30 A
Two-chain
Intermediate
flament
-Protob
Protofilament
Cross section of a hair
The fundamental structural element of a keratin is the a helix, which has 3.6 amino acid residues per turn and a rise of 5.4 A
perlum.
54A
(36)
Amino terminus
Carbon
Hydrogen
Oxygen
Nitrogen
group
Carboxyl terminus
Assuming that the biosynthesis of a helical keratin chains is the rate-limiting factor in the growth of hair, calculate the rate at
which peptide bonds of a-keratin chains must be synthesized (peptide bonds per second) to account for the observed yearly
growth of hair.
0422
rate of peptide bond formation:
Income
bonds/s
Chapter 7 Solutions
FUNDAMENTALS OF BIOCHEM.-NEXTGEN ACCESS
Ch. 7 - Prob. 1ECh. 7 - 2. Which set of binding data is likely to...Ch. 7 - Prob. 3ECh. 7 - Prob. 4ECh. 7 - 5. Drinking a few drops of a commercial...Ch. 7 - 6. Explain why long-distance runners prefer to...Ch. 7 - Prob. 7ECh. 7 - Prob. 8ECh. 7 - Prob. 9ECh. 7 - 10. In the variant hemoglobin C, glutamate at...
Ch. 7 - 11. Is myosin a fibrous protein or a globular...Ch. 7 - 12. In striated muscle, cells undergo mitosis...Ch. 7 - 13. A myosin head can undergo five ATP hydrolysis...Ch. 7 - 14. Rigor mortis, the stifle rung of muscles after...Ch. 7 - Prob. 15ECh. 7 - 16. Antibodies are well suited for recognizing...Ch. 7 - 17. Give the approximate molecular masses of an...Ch. 7 - 18. Many fish produce a tetrameric IgM. If each H...Ch. 7 - 19. Explain why the variation in VL and VH domains...Ch. 7 - 20. How many hypervariable loops are present in...Ch. 7 - Prob. 21CQCh. 7 - 22. If myoglobin had the same p50 value as...Ch. 7 - Prob. 23CQCh. 7 - Prob. 24CQCh. 7 - Prob. 25CQCh. 7 - Prob. 26CQCh. 7 - Prob. 27CQCh. 7 - Prob. 28CQCh. 7 - 29. Explain why a microfilament is polar, whereas...Ch. 7 - Prob. 30CQCh. 7 - Prob. 31CQCh. 7 - Prob. 32CQCh. 7 - Prob. 33CQCh. 7 - Prob. 34CQCh. 7 - MORE TO EXPLORE (a) Lock up information about...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- Specific rotation is a measure of a solution's capacity to rotate circularly polarized light. The unfolding of the a helix of a polypeptide to a random conformation is accompanied by a large decrease in specific rotation. Polyglutamate, a polypeptide made up of only 1-Glu residues, has the a helix conformation at pH 3. When researchers raise the pH to 7, there is a large decrease in the specific rotation of the solution. Similarly, polylysine (1.-Lys residues) is an a helix at pH 10, but when researchers lower the pH to 7 the specific rotation also decreases, as shown in the graph. a Helix Specific rotation Poly(Glu) a Helix Random conformation Poly(Lys) Random conformation T + ° 2 4 6 В 10 12 14 PH Complete the statements about the molecular mechanism for these changes in specific rotation. Increasing the pH of a polyglutamate solution from 6 to 7 causes the carboxyl group of each glutamate residue Comed Artwer lose a proton. The negatively charged groups in each glutamate residue…arrow_forwardFrom the reaction data below, determine whether the reaction is first order or second order and calculate the rate constant. Time (s) 0 Reactant (mM) 6.2 1 3.1 2 2.1 3 1.6 4 1.3 5 1.1 Only a plot of 1/[reactant] versus t gives a straight line, so the reaction is 0.150 mM-1 s-1 . S second order . The slope, k, isarrow_forwardFrom the reaction data below, determine whether the reaction is first order or second order and calculate the rate constant. Time (s) 0 Reactant (mM) 5.4 1 4.6 2 3.9 3 3.2 4 2.7 5 2.3 Only a plot of In[reactant] versus t gives a straight line, so the reaction is s-1. . The negative of the slope, k, isarrow_forward
- A protein has a molecular mass of 400 kDa when measured by size-exclusion chromatography. When subjected to gel electrophoresis in the presence of sodium dodecyl sulfate (SDS), the protein gives three bands with molecular masses of 180, 160, and 60 kDa. When electrophoresis is carried out in the presence of SDS and dithiothreitol (DTT), three bands again form, this time with molecular masses of 160, 90, and 60 kDa. How many subunits does the protein have, and what is the molecular mass of each? four subunits: 180, 160, 90, and 60 kDa three subunits: 180, 160, and 60 kDa three subunits: 160, 90, and 60 kDa four subunits: 160, 90, 90, and 60 kDa Correct Answerarrow_forwardCalculate KM and Vmax from the following data: KM= i Vmax [S] (μM) vo (mM.s-¹) 0.1 0.34 0.2 0.53 0.4 0.74 0.8 0.91 1.6 1.04 μM mM s-1arrow_forwardPropose a detailed chemical mechanism for the enzyme catalyzed reaction below and briefly note similarities, if any, to enzymes that we've studied. CO2 + CO2 2 CO2 HO CH3arrow_forward
- 11. Which of the compounds below is the major product of the following reaction sequence? NOTE: PCC is pyridinium chlorochromate 1. BH 3 PCC 2. H2O2, NaOH NH HN ΗΝ, A B C CH3NH2, NaBH3CN D E NHarrow_forward10. Which of the compounds below is the major organic product obtained from the following reaction sequence? Ph Ph Ph A B OH 1. EtMgBr H2CrO4 Zn(Hg), aq. HCI PhCHO ? 2. H₂O, H+ Ph. C D Ph "ར HO OH Earrow_forward7. What is the major organic product obtained from the following reaction sequence? Ph A OH 99 Ph OH D Br HOCH2CH2OH H2SO4 1. Mg, Et₂O 2. PhCH2CHO HCI, H₂O Br OH Ph Ph OH B C Br OH Ph Earrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
BiochemistryBiochemistryISBN:9781319114671Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.Publisher:W. H. Freeman
Lehninger Principles of BiochemistryBiochemistryISBN:9781464126116Author:David L. Nelson, Michael M. CoxPublisher:W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul...BiochemistryISBN:9781118918401Author:Donald Voet, Judith G. Voet, Charlotte W. PrattPublisher:WILEY
BiochemistryBiochemistryISBN:9781305961135Author:Mary K. Campbell, Shawn O. Farrell, Owen M. McDougalPublisher:Cengage Learning
BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning
Fundamentals of General, Organic, and Biological ...BiochemistryISBN:9780134015187Author:John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. PetersonPublisher:PEARSON
Biochemistry
Biochemistry
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:W. H. Freeman
Lehninger Principles of Biochemistry
Biochemistry
ISBN:9781464126116
Author:David L. Nelson, Michael M. Cox
Publisher:W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul...
Biochemistry
ISBN:9781118918401
Author:Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:WILEY
Biochemistry
Biochemistry
ISBN:9781305961135
Author:Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:Cengage Learning
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning
Fundamentals of General, Organic, and Biological ...
Biochemistry
ISBN:9780134015187
Author:John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:PEARSON