The reason why normal individuals do not produce antibodies against DNA and phospholipids like individuals with the autoimmune disease systemic lupus erythematosus (SLE). Concept introduction: Autoimmune diseases are a result of the immune system eliciting an immune response against self-antigens (any micro or macromolecule) produced by its own body tissues. Systemic lupus erythematosus is an autoimmune disorder where the immune system elicits an immune response against its own healthy tissues. In SLE, antibodies are produced against DNA and phospholipids. Antibodies are produced by the plasma cells that are also known as immunoglobulins, help to remove the invading pathogen.

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Chapter 7, Problem 34CQ

(a)

Summary Introduction

To explain: The reason why normal individuals do not produce antibodies against DNA and phospholipids like individuals with the autoimmune disease systemic lupus erythematosus (SLE).

Concept introduction: Autoimmune diseases are a result of the immune system eliciting an immune response against self-antigens (any micro or macromolecule) produced by its own body tissues. Systemic lupus erythematosus is an autoimmune disorder where the immune system elicits an immune response against its own healthy tissues. In SLE, antibodies are produced against DNA and phospholipids. Antibodies are produced by the plasma cells that are also known as immunoglobulins, help to remove the invading pathogen.

(b)

Summary Introduction

To explain: The reason why the antigen‒antibody complexes accumulate in the tissues of individuals with SLE.

Concept introduction: Autoimmune diseases are a result of the immune system eliciting an immune response against self-antigens (any micro or macromolecule) produced by its own body tissues. Systemic lupus erythematosus is an autoimmune disorder where the immune system elicits an immune response against its own healthy tissues. In SLE, antibodies are produced against DNA and phospholipids. Antibodies are produced by the plasma cells that are also known as immunoglobulins, help to remove the invading pathogen. Antigens are any molecule that is foreign to the body.

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