Figure 7.11 Dinitrophenol (DNP) is an "uncoupler" that makes the inner mitochondrial membrane "leaky" to protons. It was used until 1938 as a weight-loss drug. What effect would you expect DNP to have on the change in pH across the inner mitochondrial membrane? Why do you think this might be an effective weight-loss drug?

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Answer 1

Textbook Question

Chapter 7, Problem 1VCQ

Figure 7.11 Dinitrophenol (DNP) is an "uncoupler" that makes the inner mitochondrial membrane "leaky" to protons. It was used until 1938 as a weight-loss drug. What effect would you expect DNP to have on the change in pH across the inner mitochondrial membrane? Why do you think this might be an effective weight-loss drug?

Chapter 7, Problem 1VCQ, Figure 7.11 Dinitrophenol (DNP) is an "uncoupler" that makes the inner mitochondrial membrane

Expert Solution & Answer

Summary Introduction

To write:

The effect of DNP on the pH across the mitochondrial membrane and the reason that it is a weight-loss drug.

Introduction:

Dinitrophenol (DNP) is an uncoupler. The flow of electrons can be separated by DNP along with the pumping of the H+ ion for the purpose of production of ATP (adenosine triphosphate). It means that the electron transport chain can no longer form a proton gradient, and ATP synthase can no longer make ATP.

DNP is a drug given to the patient for losing weight. After using DNA as weight loss drug, a person obtains less energy out of the eaten food. One of the worst side effects of taking DNP is overheating of the body, the energy from electron transport is lost as heat.

Explanation of Solution

DNP is an uncoupler, it disrupts the ATP synthesis by leaking protons across the inner mitochondrial membrane. As a result, the proton gradient cannot be formed across the inner mitochondrial membrane as pumping of H+ (hydrogen ion) is stopped. So, there will be a decrease in pH across the inner membrane of mitochondria.

Therefore, ATP production becoming less efficient. Hence, the energy which is normally produced during cellular respiration is being wasted as heat. In such condition, majority of the eaten food could not be used for the purpose of ATP synthesis and we lose weight.

Conclusion

DNP is an effective diet drug used to lose weight. It acts as an uncoupler which disrupts the H+ gradient across mitochondrial membrane reducing ATP synthesis. Since ATP cannot be formed, the energy from electron transport is lost as heat.

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Students have asked these similar questions

Figure 7.11 Dinitrophenol (DNP) is an "uncoupler" that makes the inner mitochondrial membrane "leaky" to protons. It was used until 1938 as a weight- loss drug. What effect would you expect DNP to have on the change in pH across the inner mitochondrial membrane? Why do you think this might be an effective weight-loss drug? Intermembrane space Mitochondrial matrix ATP Synthase ADP Inner mitochondrial membrane ATP Figure 7.11 ATP synthase is a complex, molecular machine that uses a proton (H) gradient to form ATP from ADP and inorganic phosphate (Pi). (Credit: modification of work by Klaus Hoffmeier)

Cytochrome c may associate with cardiolipin (diphosphatidylglycerol) in the inner mitochondrial membrane. What sort of intermolecular forces are likely to be involved in this association?

Sodium fluoroacetate (FH2CCOO- Na+) is highly toxic. Patients with fluoroacetate poisoning accumulate citrate and fluorocitrate in their cells. Which enzyme is inhibited by fluoroacetate for this to occur? Explain.

Answer 2

Textbook Question

Chapter 7, Problem 1VCQ

Figure 7.11 Dinitrophenol (DNP) is an "uncoupler" that makes the inner mitochondrial membrane "leaky" to protons. It was used until 1938 as a weight-loss drug. What effect would you expect DNP to have on the change in pH across the inner mitochondrial membrane? Why do you think this might be an effective weight-loss drug?

Chapter 7, Problem 1VCQ, Figure 7.11 Dinitrophenol (DNP) is an "uncoupler" that makes the inner mitochondrial membrane

Expert Solution & Answer

Summary Introduction

To write:

The effect of DNP on the pH across the mitochondrial membrane and the reason that it is a weight-loss drug.

Introduction:

Dinitrophenol (DNP) is an uncoupler. The flow of electrons can be separated by DNP along with the pumping of the H+ ion for the purpose of production of ATP (adenosine triphosphate). It means that the electron transport chain can no longer form a proton gradient, and ATP synthase can no longer make ATP.

DNP is a drug given to the patient for losing weight. After using DNA as weight loss drug, a person obtains less energy out of the eaten food. One of the worst side effects of taking DNP is overheating of the body, the energy from electron transport is lost as heat.

Explanation of Solution

DNP is an uncoupler, it disrupts the ATP synthesis by leaking protons across the inner mitochondrial membrane. As a result, the proton gradient cannot be formed across the inner mitochondrial membrane as pumping of H+ (hydrogen ion) is stopped. So, there will be a decrease in pH across the inner membrane of mitochondria.

Therefore, ATP production becoming less efficient. Hence, the energy which is normally produced during cellular respiration is being wasted as heat. In such condition, majority of the eaten food could not be used for the purpose of ATP synthesis and we lose weight.

Conclusion

DNP is an effective diet drug used to lose weight. It acts as an uncoupler which disrupts the H+ gradient across mitochondrial membrane reducing ATP synthesis. Since ATP cannot be formed, the energy from electron transport is lost as heat.

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Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!

Answer 3

Textbook Question

Chapter 7, Problem 1VCQ

Figure 7.11 Dinitrophenol (DNP) is an "uncoupler" that makes the inner mitochondrial membrane "leaky" to protons. It was used until 1938 as a weight-loss drug. What effect would you expect DNP to have on the change in pH across the inner mitochondrial membrane? Why do you think this might be an effective weight-loss drug?

Chapter 7, Problem 1VCQ, Figure 7.11 Dinitrophenol (DNP) is an "uncoupler" that makes the inner mitochondrial membrane

Expert Solution & Answer

Summary Introduction

To write:

The effect of DNP on the pH across the mitochondrial membrane and the reason that it is a weight-loss drug.

Introduction:

Dinitrophenol (DNP) is an uncoupler. The flow of electrons can be separated by DNP along with the pumping of the H+ ion for the purpose of production of ATP (adenosine triphosphate). It means that the electron transport chain can no longer form a proton gradient, and ATP synthase can no longer make ATP.

DNP is a drug given to the patient for losing weight. After using DNA as weight loss drug, a person obtains less energy out of the eaten food. One of the worst side effects of taking DNP is overheating of the body, the energy from electron transport is lost as heat.

Explanation of Solution

DNP is an uncoupler, it disrupts the ATP synthesis by leaking protons across the inner mitochondrial membrane. As a result, the proton gradient cannot be formed across the inner mitochondrial membrane as pumping of H+ (hydrogen ion) is stopped. So, there will be a decrease in pH across the inner membrane of mitochondria.

Therefore, ATP production becoming less efficient. Hence, the energy which is normally produced during cellular respiration is being wasted as heat. In such condition, majority of the eaten food could not be used for the purpose of ATP synthesis and we lose weight.

Conclusion

DNP is an effective diet drug used to lose weight. It acts as an uncoupler which disrupts the H+ gradient across mitochondrial membrane reducing ATP synthesis. Since ATP cannot be formed, the energy from electron transport is lost as heat.

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Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!

Answer 4

Textbook Question

Chapter 7, Problem 1VCQ

Figure 7.11 Dinitrophenol (DNP) is an "uncoupler" that makes the inner mitochondrial membrane "leaky" to protons. It was used until 1938 as a weight-loss drug. What effect would you expect DNP to have on the change in pH across the inner mitochondrial membrane? Why do you think this might be an effective weight-loss drug?

Chapter 7, Problem 1VCQ, Figure 7.11 Dinitrophenol (DNP) is an "uncoupler" that makes the inner mitochondrial membrane

Expert Solution & Answer

Summary Introduction

To write:

The effect of DNP on the pH across the mitochondrial membrane and the reason that it is a weight-loss drug.

Introduction:

Dinitrophenol (DNP) is an uncoupler. The flow of electrons can be separated by DNP along with the pumping of the H+ ion for the purpose of production of ATP (adenosine triphosphate). It means that the electron transport chain can no longer form a proton gradient, and ATP synthase can no longer make ATP.

DNP is a drug given to the patient for losing weight. After using DNA as weight loss drug, a person obtains less energy out of the eaten food. One of the worst side effects of taking DNP is overheating of the body, the energy from electron transport is lost as heat.

Explanation of Solution

DNP is an uncoupler, it disrupts the ATP synthesis by leaking protons across the inner mitochondrial membrane. As a result, the proton gradient cannot be formed across the inner mitochondrial membrane as pumping of H+ (hydrogen ion) is stopped. So, there will be a decrease in pH across the inner membrane of mitochondria.

Therefore, ATP production becoming less efficient. Hence, the energy which is normally produced during cellular respiration is being wasted as heat. In such condition, majority of the eaten food could not be used for the purpose of ATP synthesis and we lose weight.

Conclusion

DNP is an effective diet drug used to lose weight. It acts as an uncoupler which disrupts the H+ gradient across mitochondrial membrane reducing ATP synthesis. Since ATP cannot be formed, the energy from electron transport is lost as heat.

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Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!

Answer 5

Textbook Question

Answer 6

Textbook Question

Answer 7

Expert Solution & Answer

Summary Introduction

To write:

The effect of DNP on the pH across the mitochondrial membrane and the reason that it is a weight-loss drug.

Introduction:

Dinitrophenol (DNP) is an uncoupler. The flow of electrons can be separated by DNP along with the pumping of the H+ ion for the purpose of production of ATP (adenosine triphosphate). It means that the electron transport chain can no longer form a proton gradient, and ATP synthase can no longer make ATP.

DNP is a drug given to the patient for losing weight. After using DNA as weight loss drug, a person obtains less energy out of the eaten food. One of the worst side effects of taking DNP is overheating of the body, the energy from electron transport is lost as heat.

Explanation of Solution

DNP is an uncoupler, it disrupts the ATP synthesis by leaking protons across the inner mitochondrial membrane. As a result, the proton gradient cannot be formed across the inner mitochondrial membrane as pumping of H+ (hydrogen ion) is stopped. So, there will be a decrease in pH across the inner membrane of mitochondria.

Therefore, ATP production becoming less efficient. Hence, the energy which is normally produced during cellular respiration is being wasted as heat. In such condition, majority of the eaten food could not be used for the purpose of ATP synthesis and we lose weight.

Conclusion

DNP is an effective diet drug used to lose weight. It acts as an uncoupler which disrupts the H+ gradient across mitochondrial membrane reducing ATP synthesis. Since ATP cannot be formed, the energy from electron transport is lost as heat.

Answer 8

Expert Solution & Answer

Summary Introduction

To write:

The effect of DNP on the pH across the mitochondrial membrane and the reason that it is a weight-loss drug.

Introduction:

Dinitrophenol (DNP) is an uncoupler. The flow of electrons can be separated by DNP along with the pumping of the H+ ion for the purpose of production of ATP (adenosine triphosphate). It means that the electron transport chain can no longer form a proton gradient, and ATP synthase can no longer make ATP.

DNP is a drug given to the patient for losing weight. After using DNA as weight loss drug, a person obtains less energy out of the eaten food. One of the worst side effects of taking DNP is overheating of the body, the energy from electron transport is lost as heat.

Explanation of Solution

DNP is an uncoupler, it disrupts the ATP synthesis by leaking protons across the inner mitochondrial membrane. As a result, the proton gradient cannot be formed across the inner mitochondrial membrane as pumping of H+ (hydrogen ion) is stopped. So, there will be a decrease in pH across the inner membrane of mitochondria.

Therefore, ATP production becoming less efficient. Hence, the energy which is normally produced during cellular respiration is being wasted as heat. In such condition, majority of the eaten food could not be used for the purpose of ATP synthesis and we lose weight.

Conclusion

DNP is an effective diet drug used to lose weight. It acts as an uncoupler which disrupts the H+ gradient across mitochondrial membrane reducing ATP synthesis. Since ATP cannot be formed, the energy from electron transport is lost as heat.

Answer 9

Expert Solution & Answer

Answer 10

Expert Solution & Answer

Answer 11

Summary Introduction

To write:

The effect of DNP on the pH across the mitochondrial membrane and the reason that it is a weight-loss drug.

Introduction:

Dinitrophenol (DNP) is an uncoupler. The flow of electrons can be separated by DNP along with the pumping of the H+ ion for the purpose of production of ATP (adenosine triphosphate). It means that the electron transport chain can no longer form a proton gradient, and ATP synthase can no longer make ATP.

DNP is a drug given to the patient for losing weight. After using DNA as weight loss drug, a person obtains less energy out of the eaten food. One of the worst side effects of taking DNP is overheating of the body, the energy from electron transport is lost as heat.

Answer 12

Explanation of Solution

DNP is an uncoupler, it disrupts the ATP synthesis by leaking protons across the inner mitochondrial membrane. As a result, the proton gradient cannot be formed across the inner mitochondrial membrane as pumping of H+ (hydrogen ion) is stopped. So, there will be a decrease in pH across the inner membrane of mitochondria.

Therefore, ATP production becoming less efficient. Hence, the energy which is normally produced during cellular respiration is being wasted as heat. In such condition, majority of the eaten food could not be used for the purpose of ATP synthesis and we lose weight.

Answer 13

Conclusion

DNP is an effective diet drug used to lose weight. It acts as an uncoupler which disrupts the H+ gradient across mitochondrial membrane reducing ATP synthesis. Since ATP cannot be formed, the energy from electron transport is lost as heat.

Answer 14

Ch. 7 - Figure 7.11 Dinitrophenol (DNP) is an "uncoupler"...Ch. 7 - Figure 7.12 Cyanide inhibits cytochrome c oxidase,...Ch. 7 - (Figure 7.14) Tremetol, a metabolic poison found...Ch. 7 - The energy currency used by cells is ATP ADP AMP...Ch. 7 - A reducing chemical reaction. reduces the compound...Ch. 7 - During the second half of glycolysis, what occurs?...Ch. 7 - What is removed from pyruvate during its...Ch. 7 - What do the electrons added to NAD+ do? They...Ch. 7 - GTP or ATP is produced during the conversion of...Ch. 7 - How many NADU molecules are produced on each turn...

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