Brock Biology of Microorganisms (15th Edition)
15th Edition
ISBN: 9780134261928
Author: Michael T. Madigan, Kelly S. Bender, Daniel H. Buckley, W. Matthew Sattley, David A. Stahl
Publisher: PEARSON
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Textbook Question
Chapter 6.5, Problem 3MQ
- Explain how the Pyrococcus furiosus TrmBL1 transcription regulator is able to act as both an activator and a repressor.
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Explain the fundamental differences between negative control and positive control of transcription in prokaryotes. Cite two examples of each control mechanism.
Describe the mechanism by which cAMP receptorprotein (CRP), the regulatory protein for catabolite repression, functions. Use the lactose operon as an example.
Discuss in general terms the principle of the regulation of theexpression of the trp gene with attenuation in bacteria.
Chapter 6 Solutions
Brock Biology of Microorganisms (15th Edition)
Ch. 6.1 - What is protein domain?Ch. 6.1 - Why are most DMA-binding proteins specific to...Ch. 6.1 - Describe why a protein that binds to a specific...Ch. 6.2 - Why is negative control so named?Ch. 6.2 - How does a repressor inhibit the synthesis of a...Ch. 6.2 - Induction is considered the opposite of enzyme...Ch. 6.3 - Prob. 1MQCh. 6.3 - Prob. 2MQCh. 6.3 - What is the difference between an operon and a...Ch. 6.4 - Prob. 1MQ
Ch. 6.4 - Prob. 2MQCh. 6.4 - Explain how the lac operon is both positively and...Ch. 6.4 - Prob. 1CRCh. 6.5 - What is the major difference between...Ch. 6.5 - How do transcriptional activators in Archaea often...Ch. 6.5 - Explain how the Pyrococcus furiosus TrmBL1...Ch. 6.5 - Prob. 1CRCh. 6.6 - What are kinases and what is their role in...Ch. 6.6 - Prob. 2MQCh. 6.6 - Prob. 1CRCh. 6.7 - What are the primary response regulator and the...Ch. 6.7 - Why is adaptation during chemotaxis important?Ch. 6.7 - How does the response of the chemortaxis system to...Ch. 6.7 - Adaptation allows the mechanism controlling...Ch. 6.8 - What advantage do quorum-sensing systems confer on...Ch. 6.8 - Prob. 2MQCh. 6.8 - Prob. 3MQCh. 6.8 - How can quorum sensing be considered a regulatory...Ch. 6.9 - Which Escherichia coli genes are activated and...Ch. 6.9 - Prob. 2MQCh. 6.9 - What are some other conditions that trigger the...Ch. 6.9 - Explain the sequence of molecular events that...Ch. 6.10 - Prob. 1MQCh. 6.10 - Prob. 2MQCh. 6.10 - Prob. 3MQCh. 6.10 - Prob. 1CRCh. 6.11 - Prob. 1MQCh. 6.11 - Prob. 2MQCh. 6.11 - Prob. 3MQCh. 6.11 - What are the mechanisms by which regulation by...Ch. 6.12 - What happens when a riboswitch binds the small...Ch. 6.12 - What are the major differences between a repressor...Ch. 6.12 - What is the mechanism by which a riboswitch...Ch. 6.13 - Why does attenuation control not occur in...Ch. 6.13 - Prob. 2MQCh. 6.13 - Prob. 1CRCh. 6.14 - What is feedback inhibition?Ch. 6.14 - Prob. 2MQCh. 6.14 - Prob. 3MQCh. 6.14 - Describe how feedback inhibition is reversible.Ch. 6.15 - What types of covalent modifications commonly...Ch. 6.15 - Prob. 2MQCh. 6.15 - Explain the role of an anti-sigma factor.Ch. 6.15 - Which nucleotides are commonly used to covalently...Ch. 6 - What would happen to regulation from a promoter...Ch. 6 - Most of the regulatory systems described in this...Ch. 6 - Many amino acid biosynthetic operons under...Ch. 6 - How would you design a regulatory system to make...
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- For the following types of transcriptional control, indicate whether the protein produced by the regulator gene will be synthesized initially as an active repressor or as an inactive repressor. Q. Negative control in a repressible operonarrow_forwardFor the following types of transcriptional control, indicate whether the protein produced by the regulator gene will be synthesized initially as an active repressor or as an inactive repressor. Q. Negative control in an inducible operonarrow_forwardWhat is meant by the term transcription factor modulation? List three general ways this can occur.arrow_forward
- Which molecules act as co-repressor for pur respressor in prokaryotes?arrow_forwardWhat would happen if the operator sequence of the trp operon contained a mutation that prevented the repressor protein from binding to the operator? (Explain what would happen in both the presence and absence of tryptophan)arrow_forwardHow does tryptophan affect the function of trp repressor?arrow_forward
- A researcher discovered Suramin as a potent and selective inhibitor of Mycobacterium tuberculosis RecA protein and the SOS response. What would be the outcome if the action of RecA was inhibited during the SOS response? O LexA would not autolyse, and therefore the transcription of DNA repair genes would not occur; the bacteria would likely not survive. O LexA would autolyse, and therefore the transcription of repair genes would not occur; that would be lethal to the bacteria. LexA would autolyse, and therefore the transcription of DNA repair genes would occur; and the bacteria will be susceptible to antibiotics. LexA would not autolyse, and therefore the transcription of repair genes would occur; essentially that would be lethal to the bacteria.arrow_forwardExplain how catabolite repression depends on an activatorproteinarrow_forwardOutline one mechanism used by activated mTOR to increase global translation in the cell.arrow_forward
- A number of mutations affect the expression of the lac operon in E. coli. Consider each genotype below and complete the table using “+” to indicate that the gene is expressed, and “−” to indicate that gene is not expressed.arrow_forwardTryptophan (Trp) attenuation is an extra mechanism of regulation of trp operon when trp level is too high. Attenuation causes premature transcription termination. b) Predict what will happen if trp repressor lose its allosteric effect.arrow_forwardDescribe how the components of the trp operon system are affected by a mutation in trpC? Why is it that once enviornmental tryptophan is inserted into the cell, only the trp repressor is activated (turned on)?arrow_forward
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