Human Physiology: An Integrated Approach (8th Edition)
8th Edition
ISBN: 9780134605197
Author: Dee Unglaub Silverthorn
Publisher: PEARSON
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Chapter 6.3, Problem 13CC
The extracellular fluid Ca2+ concentration averages 2.5 mmol/L. Free cytosolic Ca2+ concentration is about 0.001 mmol/L. If a cell is going to move calcium ions from its cytosol to the extracellular fluid, will it use passive or active transport? Explain.
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Students have asked these similar questions
In Chapters 11 & 12, the following examples of membrane transport proteins are given. Fill out the table with the correct answer for
that particular transport protein.
Type of transport
protein (channel or
carrier/transporter?)
K* leak channel
glucose transporter
bacteriorhodopsin
Na-K pump
glucose-Na
symport
Na-H exchanger
Performs
active or
passive
transport?
Energy source
for movement
of solute(s) or
ion(s)
Direction of movement of
solute(s) or ion(s) with
respect to the
electrochemical gradient
Na
K*
Na
glucose
Na
H'
Direction of movement
of solute(s) or ion(s)
with respect to the
membrane crossed
Na
K₁
Na'
glucose
Na
H'
Is the protein a uniport,
symport, antiport, or
none of the above?
Name the three classes of membrane transport proteins. Explain which one or ones of these classes is able to move glucose and which can move bicarbonate (HCO3−) against an electrochemical gradient. In the case of bicarbonate, but not glucose, the ΔG of the transport process has two terms. What are these two terms, and why does the second not apply to glucose? Why are cotransporters often referred to as examples of secondary active transport?
Liver cells are in contact with the blood and exchange a variety of substances with the blood plasma (the noncellular part of blood). The concentration of water is equal in the cytoplasm of liver cells and in the blood plasma. Explain this observation in terms of membrane permeability and transport mechanisms.
Animal cells typically maintain a higher concentration of Na+ outside the cell and a higher concentration of K+ inside the cell via the Na+-K+ pump. The drug ouabain inhibits the activity of the Na+-K+ pump. A nerve cell is incubated in ouabain. Predict what will happen to the concentrations of Na+ and K+ inside and outside the nerve cell as a result.
Chapter 6 Solutions
Human Physiology: An Integrated Approach (8th Edition)
Ch. 6.1 - Match the communication method on the left with...Ch. 6.1 - Which signal molecules listed in the previous...Ch. 6.1 - A cat sees a mouse and pounces on it. Do you think...Ch. 6.2 - List four components of signal pathways.Ch. 6.2 - Prob. 5CCCh. 6.2 - What are the four steps of signal transduction?Ch. 6.2 - Prob. 7CCCh. 6.2 - Prob. 8CCCh. 6.2 - Name the four categories of membrane receptors.Ch. 6.2 - Prob. 10CC
Ch. 6.2 - Prob. 11CCCh. 6.2 - Prob. 12CCCh. 6.3 - The extracellular fluid Ca2+ concentration...Ch. 6.3 - Prob. 14CCCh. 6.4 - What do receptors, enzymes, and transporters have...Ch. 6.4 - Prob. 16CCCh. 6.4 - Prob. 17CCCh. 6.5 - What is the difference between tonic control and...Ch. 6.5 - Prob. 19CCCh. 6.5 - What is the difference between local control and...Ch. 6.5 - Name the seven steps in a reflex control pathway...Ch. 6.5 - Prob. 22CCCh. 6.5 - Prob. 23CCCh. 6.5 - Prob. 24CCCh. 6 - What are the two routes for long-distance signal...Ch. 6 - Prob. 2RQCh. 6 - Prob. 3RQCh. 6 - Prob. 4RQCh. 6 - Prob. 5RQCh. 6 - An enzyme known as protein kinase adds the...Ch. 6 - Distinguish between central and peripheral...Ch. 6 - Prob. 8RQCh. 6 - Prob. 9RQCh. 6 - Prob. 10RQCh. 6 - Prob. 11RQCh. 6 - Explain the relationships of the terms in each of...Ch. 6 - List and compare the four classes of membrane...Ch. 6 - Prob. 14RQCh. 6 - Prob. 15RQCh. 6 - Prob. 16RQCh. 6 - Prob. 17RQCh. 6 - Identify the target tissue or organ for each...Ch. 6 - Now identify the integrating center for examples...Ch. 6 - In each of the following situations, identify the...Ch. 6 - Prob. 21RQCh. 6 - Prob. 22RQ
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- Name the three classes of membrane transport proteins. Explain which one or ones of these classes is able to move glucose and which can move bicarbonate (HCO3 −) against an electrochemical gradient. In the case of bicarbonate, but not glucose, the ΔG of the transport process has two terms.What are these two terms, and why does the second not apply to glucose? Why are cotransporters often referred to as examples of secondary active transport?arrow_forwardUniporters and ion channels support facilitated transport across cellular membranes. Although both are examples of facilitated transport, the rates of ion movement via an ion channel are roughly 104 - to 105 -fold faster than the rates of molecule movement via a uniporter. What key mechanisticdifference results in this large difference in transport rate?What contribution to free energy (ΔG) determines the direction of transport?arrow_forwardrate of transport Vmax 1/2Vmax transporter-mecated diffusion Km simple diffusion concentration of transported molecule The graph at left shows rates of movement across a cell membrane for a substance that uses simple diffusion (green) and a transport mechanism (red). Which of the following is TRUE about the transporters at the point shown by the arrow? A. The transporter proteins are operating more slowly than at lower concentrations. B. The transporter proteins are operating as fast as possible. C. The transporters proteins shut off at that concentration. D. The rate slows because transporter proteins run out of ATP.arrow_forward
- A cell with a K+1 concentration of 0.3 eq/L is placed into a solution with a K+1 concentration of 0.2 eq/L. It is assumed that the K+1 can pass through the cell membrane (the K+1 transport protein is open). Answer the following true or false questions. 1. K+1 will diffuse through the membrane down its concentration gradient due to Kinetic Theory 2. Movement of a solute through the membrane is called dialysis 3. K+1 will move out of the cellarrow_forwardB) Rate of transport into the cll A or B 10 20 30 40 Time (min) The graph directly above shows the rate of substance transport over time when the cells that do not contain the compounds A, B, or C, are placed in 1 mM solutions of A, B, and C, respectively. Based upon these data which of the following is/are compatible modes of transport for substance A? (active transport, facilitated diffusion, simple diffusion) For substance B? For substance C?arrow_forwardShown below are cells (colored) that were recently placed into a beaker containing a clear solution For each scenario, indicate whether movement of the molecule into the cell will occur using facilitated diffusion or active transport. А. B. 125mM 20mM fructose glucose 85MM 35mM fructose glucose OA= facilitated diffusion; B= facilitated diffusion OA= active transport; B= active transport O A= active transport; B= facilitated diffusion A= facilitated diffusion; B= active transportarrow_forward
- Consider a solute having a permeability coefficient of 10-6 m s-1 for the plasma membrane of a cylindrical Chara cell that is 100 mm long and 1 mm in diameter. Assume that its concentration remains essentially uniform within the cell. Untitled Title A. How much time would it take for 90% of the solute to diffuse out into a large external solution initially devoid of that substance?* B. How much time would it take if diffusion occurred only at the two ends of the cell?* C. How would the times calculated in A and B change for 99% of the solute to diffuse out? D. How would the times change if Pj were 10-8 m s-1?*arrow_forward1) You are studying a transport protein. It appears to bind temporarily to the molecule to be transported. During normal transport, no energy is expended. The addition of a particular molecule that closely resembles the normally transported molecule inhibits transport. An increase in the concentration of the normally transported molecule in the presence of a constant concentration of the inhibitor increases the rate of transport. What kind of transport is described? 2) What are peripheral membrane proteins?arrow_forwardPhospholipid lateral motion in membranes is characterized by a diffusion coefficient of about 1 x 10-8 cm2/sec. The distance traveled in the membrane in a given time is r = √4Dt, where r is the distance traveled in centimeters is the diffusion coefficient, and t is the time during which diffusion occurs. Calculate the distance (in nanometers) traveled by a phospholipid in a bilayer in 25 msec (milliseconds).arrow_forward
- The transport of a molecule is investigated using two chambers (left and right) separated by a synthetic membrane containing transport proteins. A solution containing varying concentrations of the molecule is added to the left side while pure water is added to the right. The transport rate of the molecule is determined by measuring the concentration of molecule that accumulates on the right side. The following table summarizes the transport rate of the molecule at various concentrations. Based on this you can conclude: a) the molecule is most likely transported by facilitated diffusion b) the molecule is moving across the membrane by passive transport c) the membrane is freely permeable to the molecule d) the molecule is most likely transported by active transportarrow_forwardWhat would happen in each of the following cases where something related to intracellular transport is altered? Assume in each case that the protein involved is a soluble protein, not a membrane protein. State where each protein would be located and explain each of your answers. You add a signal sequence (for the Golgi) to the N-terminal end of a normally cytosolic protein. You change the hydrophobic amino acids in an ER signal sequence into other, hydrophobic, amino acids.arrow_forwardFor each type of membrane transport, know the following:– Is a transporter protein required? If so, what type?– Is there an energy requirement, and if so, what is the energy source?– What is the relative rate of solute transport based on molecule type? On concentration gradient?– What are examples of the types of solutes transported by carriers and channels?arrow_forward
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