Microbiology Fundamentals: A Clinical Approach
3rd Edition
ISBN: 9781259709227
Author: Marjorie Kelly Cowan Professor, Heidi Smith
Publisher: McGraw-Hill Education
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Chapter 6.2, Problem 8AYP
List and define five terms used to express the temperature-related growth capabilities of microbes.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 6 Solutions
Microbiology Fundamentals: A Clinical Approach
Ch. 6.1 - List the essential nutrients of a bacterial cell.Ch. 6.1 - Prob. 2AYPCh. 6.1 - List and define four different terms that describe...Ch. 6.1 - Prob. 4AYPCh. 6.1 - Compare and contrast the processes of diffusion...Ch. 6.1 - Identify the effects of isotonic, hypotonic, and...Ch. 6.1 - Name two types of passive transport and one type...Ch. 6.1 - Prob. 1NPCh. 6.1 - Prob. 2NPCh. 6.1 - Prob. 3NP
Ch. 6.1 - Prob. 1MMCh. 6.2 - List and define five terms used to express the...Ch. 6.2 - Summarize three ways in which microorganisms...Ch. 6.2 - Identify three important environmental factors...Ch. 6.2 - List and describe the five types of associations...Ch. 6.2 - Discuss characteristics of biofilms that...Ch. 6.2 - Which statements are true with respect to...Ch. 6.3 - Summarize the steps of cell division used by most...Ch. 6.3 - Define doubling time, and describe how it leads to...Ch. 6.3 - Compare and contrast the four phases of growth in...Ch. 6.3 - Identify one culture-based and one...Ch. 6.3 - Prob. 2MMCh. 6 - Which descriptors are likely to have applied to...Ch. 6 - Prob. 2QCh. 6 - Speculate about how earths atmosphere came to...Ch. 6 - Which of the following is true of passive...Ch. 6 - Compare the effects of a hypertonic, hypotonic,...Ch. 6 - Usually scientists looking for life on other...Ch. 6 - An organism that can synthesize all its required...Ch. 6 - Provide evidence in support of or refuting this...Ch. 6 - Develop an explanation for why biofilm bacteria...Ch. 6 - Most bacteria increase their numbers by a. sexual...Ch. 6 - Looking at figure 6.3, explain how a cell in a...Ch. 6 - In binary fission, the parent chromosome is...Ch. 6 - A cell exposed to a hypertonic environment will...Ch. 6 - Prob. 14QCh. 6 - Bacteria and archaea are ubiquitous on the planet....Ch. 6 - Prob. 16QCh. 6 - How can you explain the fact that an unopened...Ch. 6 - Prob. 18QCh. 6 - In a viable count, each ____ represents a ______...Ch. 6 - If an egg salad sandwich sitting in a car on a...Ch. 6 - Scientists now believe that most bacteria in...Ch. 6 - Prob. 1VC
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