HUMAN ANATOMY
6th Edition
ISBN: 9781260210262
Author: SALADIN
Publisher: RENT MCG
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Chapter 6.2, Problem 1AWYK
Considering the function of osteoblasts, what organelles do you think are especially abundant in their cytoplasm?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
MAKE SURE ANSWERS HAVE UNITS if appropriate.
SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 6 Solutions
HUMAN ANATOMY
Ch. 6.1 - Prob. 1BYGOCh. 6.1 - List three or more functions of the skeletal...Ch. 6.1 - Prob. 3BYGOCh. 6.1 - Prob. 4BYGOCh. 6.1 - Prob. 5BYGOCh. 6.2 - Considering the function of osteoblasts, what...Ch. 6.2 - Suppose you had unlabeled electron micrographs of...Ch. 6.2 - Prob. 7BYGOCh. 6.2 - Prob. 8BYGOCh. 6.2 - Sketch a cross section of an osteon and label its...
Ch. 6.2 - What are the two kinds of bone marrow? What does...Ch. 6.3 - Prob. 1AWYKCh. 6.3 - Describe the stages of endochondral ossification....Ch. 6.3 - Prob. 12BYGOCh. 6.3 - How does Wolff’s law explain some of the...Ch. 6.3 - Prob. 14BYGOCh. 6.3 - Prob. 15BYGOCh. 6.4 - Name and describe any five types of bone...Ch. 6.4 - What is a callus? How does it contribute to...Ch. 6.4 - Prob. 18BYGOCh. 6 - Components of the skeletal system, including but...Ch. 6 - Seven function of the skeletal systemCh. 6 - The constituents of a bone, including but not...Ch. 6 - Prob. 6.1.4AYLOCh. 6 - The spatial relationship between compact and...Ch. 6 - Prob. 6.1.6AYLOCh. 6 - Prob. 6.1.7AYLOCh. 6 - Prob. 6.2.1AYLOCh. 6 - The spectalized structure of an osteocyte and how...Ch. 6 - Prob. 6.2.3AYLOCh. 6 - The composition of the bone matrix and the...Ch. 6 - Prob. 6.2.5AYLOCh. 6 - Prob. 6.2.6AYLOCh. 6 - The two kinds of bone marrow, their locations in...Ch. 6 - The two modes of bone development (ossification)...Ch. 6 - Prob. 6.3.2AYLOCh. 6 - The stages of endochondral ossification, replacing...Ch. 6 - Structural differences between the endochondral...Ch. 6 - The zones of tissue found in the metaphysis of a...Ch. 6 - Prob. 6.3.6AYLOCh. 6 - How bones grow in thickness and change shape even...Ch. 6 - Prob. 6.3.8AYLOCh. 6 - The nutrients needed for bone growth and...Ch. 6 - Hormones that regulate bone growth and remodelingCh. 6 - Prob. 6.3.11AYLOCh. 6 - Prob. 6.4.1AYLOCh. 6 - Prob. 6.4.2AYLOCh. 6 - Prob. 6.4.3AYLOCh. 6 - Prob. 6.4.4AYLOCh. 6 - Osteoporosis risk factors, prevention, diagnosis,...Ch. 6 - Causes, signs, and symptoms of rickets and...Ch. 6 - Which cells have a ruffled border and secrete...Ch. 6 - The medullary cavity of a child’s bone may contain...Ch. 6 - The long bones of the limbs grow in length by cell...Ch. 6 - Prob. 4TYRCh. 6 - Prob. 5TYRCh. 6 - Prob. 6TYRCh. 6 - Prob. 7TYRCh. 6 - Prob. 8TYRCh. 6 - Prob. 9TYRCh. 6 - Prob. 10TYRCh. 6 - Prob. 11TYRCh. 6 - Prob. 12TYRCh. 6 - Prob. 13TYRCh. 6 - Prob. 14TYRCh. 6 - Prob. 15TYRCh. 6 - Prob. 16TYRCh. 6 - Prob. 17TYRCh. 6 - Prob. 18TYRCh. 6 - Prob. 19TYRCh. 6 - Prob. 20TYRCh. 6 - Prob. 1BYMVCh. 6 - Prob. 2BYMVCh. 6 - Prob. 3BYMVCh. 6 - Prob. 4BYMVCh. 6 - Prob. 5BYMVCh. 6 - Prob. 6BYMVCh. 6 - Prob. 7BYMVCh. 6 - Prob. 8BYMVCh. 6 - Prob. 9BYMVCh. 6 - State a meaning of each word element and give a...Ch. 6 - Prob. 1WWWTSCh. 6 - Prob. 2WWWTSCh. 6 - Briefly explain why each of the following...Ch. 6 - Prob. 4WWWTSCh. 6 - Briefly explain why each of the following...Ch. 6 - Prob. 6WWWTSCh. 6 - Prob. 7WWWTSCh. 6 - Prob. 8WWWTSCh. 6 - Prob. 9WWWTSCh. 6 - Briefly explain why each of the following...Ch. 6 - Prob. 1TYCCh. 6 - Prob. 2TYCCh. 6 - One of the more common fractures in children and...Ch. 6 - Prob. 4TYCCh. 6 - Prob. 5TYC
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