HUMAN ANATOMY
6th Edition
ISBN: 9781260210262
Author: SALADIN
Publisher: RENT MCG
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Chapter 6, Problem 1TYC
Summary Introduction
Interpretation:
The arrangement through which oesteocytesreceives oxygen and nutrients is to be determined.
Concept introduction:
An osteon is the smallest structure that makes up a compact bone. It is a rod-shaped structure which contains haversian canals. These canals contain blood vessels, nerves, lymphatic vessels, etc.
Osteocytes cell are a type of bone cell that are derived from osteoblast cells.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 6 Solutions
HUMAN ANATOMY
Ch. 6.1 - Prob. 1BYGOCh. 6.1 - List three or more functions of the skeletal...Ch. 6.1 - Prob. 3BYGOCh. 6.1 - Prob. 4BYGOCh. 6.1 - Prob. 5BYGOCh. 6.2 - Considering the function of osteoblasts, what...Ch. 6.2 - Suppose you had unlabeled electron micrographs of...Ch. 6.2 - Prob. 7BYGOCh. 6.2 - Prob. 8BYGOCh. 6.2 - Sketch a cross section of an osteon and label its...
Ch. 6.2 - What are the two kinds of bone marrow? What does...Ch. 6.3 - Prob. 1AWYKCh. 6.3 - Describe the stages of endochondral ossification....Ch. 6.3 - Prob. 12BYGOCh. 6.3 - How does Wolff’s law explain some of the...Ch. 6.3 - Prob. 14BYGOCh. 6.3 - Prob. 15BYGOCh. 6.4 - Name and describe any five types of bone...Ch. 6.4 - What is a callus? How does it contribute to...Ch. 6.4 - Prob. 18BYGOCh. 6 - Components of the skeletal system, including but...Ch. 6 - Seven function of the skeletal systemCh. 6 - The constituents of a bone, including but not...Ch. 6 - Prob. 6.1.4AYLOCh. 6 - The spatial relationship between compact and...Ch. 6 - Prob. 6.1.6AYLOCh. 6 - Prob. 6.1.7AYLOCh. 6 - Prob. 6.2.1AYLOCh. 6 - The spectalized structure of an osteocyte and how...Ch. 6 - Prob. 6.2.3AYLOCh. 6 - The composition of the bone matrix and the...Ch. 6 - Prob. 6.2.5AYLOCh. 6 - Prob. 6.2.6AYLOCh. 6 - The two kinds of bone marrow, their locations in...Ch. 6 - The two modes of bone development (ossification)...Ch. 6 - Prob. 6.3.2AYLOCh. 6 - The stages of endochondral ossification, replacing...Ch. 6 - Structural differences between the endochondral...Ch. 6 - The zones of tissue found in the metaphysis of a...Ch. 6 - Prob. 6.3.6AYLOCh. 6 - How bones grow in thickness and change shape even...Ch. 6 - Prob. 6.3.8AYLOCh. 6 - The nutrients needed for bone growth and...Ch. 6 - Hormones that regulate bone growth and remodelingCh. 6 - Prob. 6.3.11AYLOCh. 6 - Prob. 6.4.1AYLOCh. 6 - Prob. 6.4.2AYLOCh. 6 - Prob. 6.4.3AYLOCh. 6 - Prob. 6.4.4AYLOCh. 6 - Osteoporosis risk factors, prevention, diagnosis,...Ch. 6 - Causes, signs, and symptoms of rickets and...Ch. 6 - Which cells have a ruffled border and secrete...Ch. 6 - The medullary cavity of a child’s bone may contain...Ch. 6 - The long bones of the limbs grow in length by cell...Ch. 6 - Prob. 4TYRCh. 6 - Prob. 5TYRCh. 6 - Prob. 6TYRCh. 6 - Prob. 7TYRCh. 6 - Prob. 8TYRCh. 6 - Prob. 9TYRCh. 6 - Prob. 10TYRCh. 6 - Prob. 11TYRCh. 6 - Prob. 12TYRCh. 6 - Prob. 13TYRCh. 6 - Prob. 14TYRCh. 6 - Prob. 15TYRCh. 6 - Prob. 16TYRCh. 6 - Prob. 17TYRCh. 6 - Prob. 18TYRCh. 6 - Prob. 19TYRCh. 6 - Prob. 20TYRCh. 6 - Prob. 1BYMVCh. 6 - Prob. 2BYMVCh. 6 - Prob. 3BYMVCh. 6 - Prob. 4BYMVCh. 6 - Prob. 5BYMVCh. 6 - Prob. 6BYMVCh. 6 - Prob. 7BYMVCh. 6 - Prob. 8BYMVCh. 6 - Prob. 9BYMVCh. 6 - State a meaning of each word element and give a...Ch. 6 - Prob. 1WWWTSCh. 6 - Prob. 2WWWTSCh. 6 - Briefly explain why each of the following...Ch. 6 - Prob. 4WWWTSCh. 6 - Briefly explain why each of the following...Ch. 6 - Prob. 6WWWTSCh. 6 - Prob. 7WWWTSCh. 6 - Prob. 8WWWTSCh. 6 - Prob. 9WWWTSCh. 6 - Briefly explain why each of the following...Ch. 6 - Prob. 1TYCCh. 6 - Prob. 2TYCCh. 6 - One of the more common fractures in children and...Ch. 6 - Prob. 4TYCCh. 6 - Prob. 5TYC
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