Growth factors are substances which are available in nature. For example, vitamins are growth factors needed for stimulating the growth of the microbial cells. These are additional requirements apart from the major nutrients like carbon, hydrogen, nitrogen, and so on.

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Chapter 6, Problem 4FIB

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Growth factors are substances which are available in nature. For example, vitamins are growth factors needed for stimulating the growth of the microbial cells. These are additional requirements apart from the major nutrients like carbon, hydrogen, nitrogen, and so on.

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.

2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0 Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…

The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?

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Question

Chapter 6, Problem 4FIB

Summary Introduction

Introduction:

Growth factors are substances which are available in nature. For example, vitamins are growth factors needed for stimulating the growth of the microbial cells. These are additional requirements apart from the major nutrients like carbon, hydrogen, nitrogen, and so on.

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Question

Chapter 6, Problem 4FIB

Summary Introduction

Introduction:

Growth factors are substances which are available in nature. For example, vitamins are growth factors needed for stimulating the growth of the microbial cells. These are additional requirements apart from the major nutrients like carbon, hydrogen, nitrogen, and so on.

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Answer 4

Question

Chapter 6, Problem 4FIB

Summary Introduction

Introduction:

Growth factors are substances which are available in nature. For example, vitamins are growth factors needed for stimulating the growth of the microbial cells. These are additional requirements apart from the major nutrients like carbon, hydrogen, nitrogen, and so on.

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Answer 5

Chapter 6, Problem 4FIB

Summary Introduction

Introduction:

Growth factors are substances which are available in nature. For example, vitamins are growth factors needed for stimulating the growth of the microbial cells. These are additional requirements apart from the major nutrients like carbon, hydrogen, nitrogen, and so on.

Answer 6

Chapter 6, Problem 4FIB

Summary Introduction

Introduction:

Growth factors are substances which are available in nature. For example, vitamins are growth factors needed for stimulating the growth of the microbial cells. These are additional requirements apart from the major nutrients like carbon, hydrogen, nitrogen, and so on.

Answer 7

Chapter 6, Problem 4FIB

Summary Introduction

Introduction:

Growth factors are substances which are available in nature. For example, vitamins are growth factors needed for stimulating the growth of the microbial cells. These are additional requirements apart from the major nutrients like carbon, hydrogen, nitrogen, and so on.

Answer 8

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Growth factors are substances which are available in nature. For example, vitamins are growth factors needed for stimulating the growth of the microbial cells. These are additional requirements apart from the major nutrients like carbon, hydrogen, nitrogen, and so on.

Solution Summary: The author explains that growth factors are small organic molecules that are required in minute amounts for metabolism.

Concept explainers

Introduction:

Growth factors are substances which are available in nature. For example, vitamins are growth factors needed for stimulating the growth of the microbial cells. These are additional requirements apart from the major nutrients like carbon, hydrogen, nitrogen, and so on.

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Chapter 6 Solutions

Growth factors are substances which are available in nature. For example, vitamins are growth factors needed for stimulating the growth of the microbial cells. These are additional requirements apart from the major nutrients like carbon, hydrogen, nitrogen, and so on.

Solution Summary: The author explains that growth factors are small organic molecules that are required in minute amounts for metabolism.

Concept explainers

Introduction: Growth factors are substances which are available in nature. For example, vitamins are growth factors needed for stimulating the growth of the microbial cells. These are additional requirements apart from the major nutrients like carbon, hydrogen, nitrogen, and so on.

Want to see the full answer?

Chapter 6 Solutions

Introduction:

Growth factors are substances which are available in nature. For example, vitamins are growth factors needed for stimulating the growth of the microbial cells. These are additional requirements apart from the major nutrients like carbon, hydrogen, nitrogen, and so on.