NESTER'S MICROBIOLOGY-CONNECT >CUSTOM<
9th Edition
ISBN: 9781265432287
Author: Anderson
Publisher: MCG CUSTOM
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Chapter 6, Problem 3SA
How do enzymes catalyze
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Biopharmaceutics and Pharmacokinetics:Two-Compartment Model Instant Absorption Questions
SHOW ALL WORK, including equation used, variables used and each step to your solution, report your regression lines and axes names (with units if appropriate) :Calculate a-q
a) B1,
b) B2,
c) hybrid rate constant (1)
d) hybrid rate constant (2)
e) t1/2,dist
f) t1/2,elim
g) k10
h) k12
i) k21
j) initial concentration (C0)
k) central compartment volume (V1)
l) steady-state volume (Vss)
m) clearance (CL) AUC (0→10 min) using trapezoidal rule
n) AUC (20→30 min) using trapezoidal rule
o) AUCtail (AUC360→∞)
p) total AUC (using short cut method)
q) volume from AUC (VAUC)
Glitazones reduce insulin resistance by binding to a transcription factor in adipocytes, thereby reducing thesecretion of fatty acids. Glitazones are taken orally (in pill form). Using pharmacokinetic modeling, deriveequations to describe how the concentration of glitazones varies in the plasma as a function of time. Yourequations should be of the form: dCglitazone /dt = something, or dMglitazone /dt = something. Your model shouldinclude three compartments: the gut, the plasma, and the fatty tissues. Make sure to include a diagram thatillustrates your thinking, state all assumptions, and define your variables. Do not solve the equations.
Chapter 6 Solutions
NESTER'S MICROBIOLOGY-CONNECT >CUSTOM<
Ch. 6 - Explain the difference between catabolism and...Ch. 6 - How does ATP serve as a carrier of free energy?Ch. 6 -
3. How do enzymes catalyze chemical reactions?
Ch. 6 - Explain how precursor molecules are involved in...Ch. 6 -
5. How do cells regulate enzyme activity?
Ch. 6 - Why do the electrons carried by FADH2 result in...Ch. 6 -
7. Name three food products produced with the aid...Ch. 6 - In photosynthesis, what is encompassed by the term...Ch. 6 - Unlike the cyanobacteria, the anoxygenic...Ch. 6 - What is the role of transamination in amino acid...
Ch. 6 - Which of these factors do does not affect enzyme...Ch. 6 - Which of the following statements is false?...Ch. 6 - Based on the name, NADH dehydrogenase is a) a...Ch. 6 - What is the end product of glycolysis? a) Glucose...Ch. 6 -
5. The central metabolic pathway(s) is/are
a)...Ch. 6 - Which of these pathways gives a cell the potential...Ch. 6 - In fermentation, the terminal electron acceptor is...Ch. 6 -
8. In the process of oxidative phosphorylation,...Ch. 6 - If a bacterium loses the ability to produce FADH2,...Ch. 6 - Degradation of fats as an energy source involves...Ch. 6 -
1. A worker in a cheese-making facility argues...Ch. 6 -
2. Scientists working with DNA in vitro often...Ch. 6 -
1. A student argued that aerobic and anaerobic...Ch. 6 - Chemolithotrophs near hydrothermal vents support a...
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- The Oregon Wolfe Barley mapping population is unique in having 12 easily-scored morphological markers, each showing monogenic inheritance. Do you consider these markers useful? Briefly defend your answer, pointing out advantages and disadvantages of morphological vs. molecular markers.arrow_forwardBiopharmaceutics and Pharmacokinetics:Two-Compartment Model Instant Absorption Questions Calculate these : a) B1, b) B2, c) hybrid rate constant (1) d) hybrid rate constant (2) e) t1/2,dist f) t1/2,elim g) k10 h) k12 i) k21 j) initial concentration (C0) k) central compartment volume (V1) l) steady-state volume (Vss) m) clearance (CL) AUC (0→10 min) using trapezoidal rule n) AUC (20→30 min) using trapezoidal rule o) AUCtail (AUC360→∞) p) total AUC (using short cut method) q) volume from AUC (VAUC)arrow_forwardIn a population of Jackalopes (pictured below), horn length will vary between 0.5 and 2 feet, with the mean length somewhere around 1.05 feet. You pick Jackalopes that have horn lengths around 1.75 feet to breed as this appears to be the optimal length for battling other Jackalopes for food. After a round of breeding, you measure the offsprings' mean horn length is 1.67. What is the heritability of horns length (h2)? Is Jackalope horn length a heritable trait? (4 pts)? 12pt v R Paragraph V BIU A श्र > Barrow_forward
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