Fundamentals of Biostatistics
8th Edition
ISBN: 9781305268920
Author: Bernard Rosner
Publisher: Cengage Learning
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Chapter 6, Problem 22P
A nine-laboratory cooperative study was performed to evaluate quality control for susceptibility tests with 30-μg netilmicin disks [6]. Each laboratory tested three standard control strains on a different lot of Mueller-Hinton agar, with 150 tests performed per laboratory. For protocol control, each laboratory also performed 15 additional tests on each of the control strains using the same lot of Mueller-Hinton agar across laboratories. The mean zone diameters for each of the nine laboratories are given in Table 6.11.
Are there any advantages to using a common medium versus using different media for performing the susceptibility tests with regard to standardization of results across laboratories?
Table 6.11 Mean zone diameters with 30-μg netilmicin disks tested in nine separate laboratories
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A nine-laboratory cooperative study was performed toevaluate quality control for susceptibility tests with 30-μgnetilmicin disks . Each laboratory tested three standardcontrol strains on a different lot of Mueller-Hinton agar, with150 tests performed per laboratory. For protocol control,each laboratory also performed 15 additional tests on eachof the control strains using the same lot of Mueller-Hintonagar across laboratories. The mean zone diameters for eachof the nine laboratories are given in the image.Problem a ) Provide a point and interval estimate (95% CI) forthe mean zone diameter across laboratories for each typeof control strain, assuming each laboratory uses differentmedia to perform the susceptibility tests.Problem b ) Answer Problem a assuming each laboratory usesa common medium to perform the susceptibility tests.Problem c ) Provide a point and interval estimate (95% CI) for theinterlaboratory standard deviation of mean zone diametersfor each type of control strain,…
The drug BGH (Bovine Growth Hormone) is reported to increase the milk production
in dairy cows. It is known that the average milk production of dairy cows not using
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Chapter 6 Solutions
Fundamentals of Biostatistics
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