CONNECT ACCESS CARD FOR ANATOMY AND PHYSIOLOGY
8th Edition
ISBN: 9781259880193
Author: SALADIN
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Chapter 5.6, Problem 26BYGO
Summary Introduction
Introduction:
A group of cells make the whole human body. The death of cells from the embryonic origin is called apoptosis or programmed cell death. In some cases, the cells die because of an injury caused by a scrape or harmful chemicals, which leads to inflammation or necrosis. These two factors are most common in human body, and it can be controlled by human body mechanism accordingly.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 5 Solutions
CONNECT ACCESS CARD FOR ANATOMY AND PHYSIOLOGY
Ch. 5.1 - Classify each of the following into one of the...Ch. 5.1 - What are tissues composed of in addition to cells?Ch. 5.1 - Prob. 3BYGOCh. 5.1 - Prob. 4BYGOCh. 5.1 - Two names for the branch of biology concerned with...Ch. 5.1 - Prob. 2AYLOCh. 5.1 - The roles of cells, matrix, fibers, and ground...Ch. 5.1 - Primary germ layers of the embryo and their...Ch. 5.1 - Prob. 5AYLOCh. 5.2 - Distinguish between simple and stratified...
Ch. 5.2 - Prob. 6BYGOCh. 5.2 - Prob. 7BYGOCh. 5.2 - Prob. 8BYGOCh. 5.2 - Prob. 1AYLOCh. 5.2 - Prob. 2AYLOCh. 5.2 - 5.2 Epithelial Tissue 3. Defining characteristics...Ch. 5.2 - Prob. 4AYLOCh. 5.2 - Prob. 5AYLOCh. 5.2 - Prob. 6AYLOCh. 5.2 - Prob. 7AYLOCh. 5.2 - Prob. 8AYLOCh. 5.2 - Prob. 9AYLOCh. 5.3 - What features do most or all connective tissues...Ch. 5.3 - Prob. 10BYGOCh. 5.3 - Prob. 11BYGOCh. 5.3 - Prob. 12BYGOCh. 5.3 - Discuss the difference between dense regular and...Ch. 5.3 - Prob. 14BYGOCh. 5.3 - Prob. 15BYGOCh. 5.3 - Prob. 1AYLOCh. 5.3 - Prob. 2AYLOCh. 5.3 - Prob. 3AYLOCh. 5.3 - Prob. 4AYLOCh. 5.3 - Prob. 5AYLOCh. 5.3 - 5.3 Connective Tissue 6. The appearance,...Ch. 5.3 - Prob. 7AYLOCh. 5.3 - Prob. 8AYLOCh. 5.3 - Prob. 9AYLOCh. 5.3 - Prob. 10AYLOCh. 5.3 - 5.3 Connective Tissue 11. Why blood is classified...Ch. 5.4 - Prob. 16BYGOCh. 5.4 - Prob. 17BYGOCh. 5.4 - Prob. 18BYGOCh. 5.4 - Prob. 1AYLOCh. 5.4 - Prob. 2AYLOCh. 5.4 - Prob. 3AYLOCh. 5.4 - 5.4 Nervous and Muscular TissuesExcitable Tissues...Ch. 5.4 - Prob. 5AYLOCh. 5.5 - Prob. 19BYGOCh. 5.5 - Prob. 20BYGOCh. 5.5 - Prob. 21BYGOCh. 5.5 - Prob. 22BYGOCh. 5.5 - Prob. 23BYGOCh. 5.5 - Prob. 1AYLOCh. 5.5 - Prob. 2AYLOCh. 5.5 - Prob. 3AYLOCh. 5.5 - Prob. 4AYLOCh. 5.5 - Prob. 5AYLOCh. 5.5 - Prob. 6AYLOCh. 5.5 - Prob. 7AYLOCh. 5.5 - 5.5 Cell Junctions, Glands, and Membranes 8....Ch. 5.5 - 5.5 Cell Junctions, Glands, and Membranes 9....Ch. 5.5 - Prob. 10AYLOCh. 5.6 - Distinguish between differentiation and...Ch. 5.6 - Prob. 25BYGOCh. 5.6 - Prob. 26BYGOCh. 5.6 - Distinguish between regeneration and fibrosis....Ch. 5.6 - Prob. 1AYLOCh. 5.6 - Prob. 2AYLOCh. 5.6 - 5.6 Tissue Growth, Development, Repair, and...Ch. 5.6 - Prob. 4AYLOCh. 5.6 - Prob. 5AYLOCh. 5.6 - Prob. 6AYLOCh. 5.6 - Prob. 7AYLOCh. 5.6 - 5.6 Tissue Growth, Development, Repair, and...Ch. 5 - Transitional epithelium is found is a. the urinary...Ch. 5 - Prob. 2TYRCh. 5 - Which of these is a primary germ layer? a....Ch. 5 - A seminiferous tubule of the testis is lined with...Ch. 5 - Prob. 5TYRCh. 5 - A fixative serves to a. stop tissue decay. b....Ch. 5 - Prob. 7TYRCh. 5 - Prob. 8TYRCh. 5 - Prob. 9TYRCh. 5 - Prob. 10TYRCh. 5 - Prob. 11TYRCh. 5 - Prob. 12TYRCh. 5 - Prob. 13TYRCh. 5 - Prob. 14TYRCh. 5 - Tendons and ligaments are made mainly of the...Ch. 5 - Prob. 16TYRCh. 5 - Prob. 17TYRCh. 5 - Fibers and ground substance make up the ______ of...Ch. 5 - A/An _______ adult stem cell can differentiate...Ch. 5 - Prob. 20TYRCh. 5 - Prob. 1BYMVCh. 5 - Prob. 2BYMVCh. 5 - State a meaning of each word element, and give a...Ch. 5 - Prob. 4BYMVCh. 5 - Prob. 5BYMVCh. 5 - State a meaning of each word element, and give a...Ch. 5 - Prob. 7BYMVCh. 5 - Prob. 8BYMVCh. 5 - Prob. 9BYMVCh. 5 - Prob. 10BYMVCh. 5 - The esophagus is protected from abrasion by a...Ch. 5 - Prob. 2WWTSCh. 5 - Prob. 3WWTSCh. 5 - Prob. 4WWTSCh. 5 - Prob. 5WWTSCh. 5 - Prob. 6WWTSCh. 5 - Prob. 7WWTSCh. 5 - Prob. 8WWTSCh. 5 - Prob. 9WWTSCh. 5 - Prob. 10WWTSCh. 5 - A woman in labor is often told to push. In doing...Ch. 5 - A major tenet of the cell theory is that all...Ch. 5 - Prob. 3TYCCh. 5 - The epithelium of the respiratory tract is mostly...Ch. 5 - Which do you think would heal faster, cartilage or...
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