
Concept explainers
To write:
Disadvantages and advantages of using COX-2 inhibitors, rather than NSAIDs, to treat pain.
Introduction:
NSAIDs are non-steroidal anti-inflammatory drugs. They are the traditional doses for pain and fever. They are the analgesics and work on the cyclooxygenases. Cyclooxygenases are of two types, cyclooxygenase-2(COX-2) and cyclooxygenase-1 (COX-1). NSAIDs work by inhibiting the secretion of prostaglandin. COX-1 is placed in the stomach lining and COX-2 is responsible for the secretion of proinflammatory cytokinin and prostaglandins that mediate inflammatory responses and pain. So, the work of NSAIDs is to bind to the active site of the enzyme and blocking its functioning.

Want to see the full answer?
Check out a sample textbook solution
Chapter 5 Solutions
Principles of Human Physiology Plus Mastering A&P with Pearson eText - Access Card Package (6th Edition)
- 22. Which of the following mutant proteins is expected to have a dominant negative effect when over- expressed in normal cells? a. mutant PI3-kinase that lacks the SH2 domain but retains the kinase function b. mutant Grb2 protein that cannot bind to RTK c. mutant RTK that lacks the extracellular domain d. mutant PDK that has the PH domain but lost the kinase function e. all of the abovearrow_forwardWhat is the label ?arrow_forwardCan you described the image? Can you explain the question as well their answer and how to get to an answer to an problem like this?arrow_forward
- Describe the principle of homeostasis.arrow_forwardExplain how the hormones of the glands listed below travel around the body to target organs and tissues : Pituitary gland Hypothalamus Thyroid Parathyroid Adrenal Pineal Pancreas(islets of langerhans) Gonads (testes and ovaries) Placentaarrow_forwardWhat are the functions of the hormones produced in the glands listed below: Pituitary gland Hypothalamus Thyroid Parathyroid Adrenal Pineal Pancreas(islets of langerhans) Gonads (testes and ovaries) Placentaarrow_forward
- Describe the hormones produced in the glands listed below: Pituitary gland Hypothalamus Thyroid Parathyroid Adrenal Pineal Pancreas(islets of langerhans) Gonads (testes and ovaries) Placentaarrow_forwardPlease help me calculate drug dosage from the following information: Patient weight: 35 pounds, so 15.9 kilograms (got this by dividing 35 pounds by 2.2 kilograms) Drug dose: 0.05mg/kg Drug concentration: 2mg/mLarrow_forwardA 25-year-old woman presents to the emergency department with a 2-day history of fever, chills, severe headache, and confusion. She recently returned from a trip to sub-Saharan Africa, where she did not take malaria prophylaxis. On examination, she is febrile (39.8°C/103.6°F) and hypotensive. Laboratory studies reveal hemoglobin of 8.0 g/dL, platelet count of 50,000/μL, and evidence of hemoglobinuria. A peripheral blood smear shows ring forms and banana-shaped gametocytes. Which of the following Plasmodium species is most likely responsible for her severe symptoms? A. Plasmodium vivax B. Plasmodium ovale C. Plasmodium malariae D. Plasmodium falciparumarrow_forward
- Human Anatomy & Physiology (11th Edition)BiologyISBN:9780134580999Author:Elaine N. Marieb, Katja N. HoehnPublisher:PEARSONBiology 2eBiologyISBN:9781947172517Author:Matthew Douglas, Jung Choi, Mary Ann ClarkPublisher:OpenStaxAnatomy & PhysiologyBiologyISBN:9781259398629Author:McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa StouterPublisher:Mcgraw Hill Education,
- Molecular Biology of the Cell (Sixth Edition)BiologyISBN:9780815344322Author:Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter WalterPublisher:W. W. Norton & CompanyLaboratory Manual For Human Anatomy & PhysiologyBiologyISBN:9781260159363Author:Martin, Terry R., Prentice-craver, CynthiaPublisher:McGraw-Hill Publishing Co.Inquiry Into Life (16th Edition)BiologyISBN:9781260231700Author:Sylvia S. Mader, Michael WindelspechtPublisher:McGraw Hill Education





