Biology
Biology
4th Edition
ISBN: 9781259188121
Author: Peter Stiling, Robert Brooker, Linda Graham, Eric Widmaier
Publisher: McGraw-Hill Education
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Chapter 51.1, Problem 1EQ

CoreSKILL » How did Paland and Lynch test the hypothesis that sexual reproduction reduced the frequency of deleterious mutations in a population?

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1a) In a very large population, if the forward and reverse mutation rates are exactly the same, how would you expect the frequency of an original, non-mutated allele to change in the population over time? Will the population eventually achieve an equilibrium value of the frequency of the non-mutated allele? b) What if the forward mutation rate is one order of magnitude larger (e. 10X) than the reverse mutation rate? Do you expect the frequency of the original, non-mutated allele to increase, decrease, or stay the same over time?  c) If the population size is considerably smaller, does this change your expectations for changes in the frequency of the original, non-mutated allele over several generations?
Steven Frank and Laurence Hurst argued that a cytoplasmically inherited mutation in humans that has severe effects in males but no effect in females will not be eliminated from a population by natural selection because only females pass on mtDNA (S. A. Frank and L. D. Hurst. 1996. Nature 383:224). Using this argument, explain why males with Leber hereditary optic neuropathy are more severely affected than females.
Pls help ASAP

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