BROOKER BIOLOGY
BROOKER BIOLOGY
5th Edition
ISBN: 9781307656152
Author: BROOKER
Publisher: MCG/CREATE
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Chapter 50.4, Problem 2CC
Summary Introduction

To explain: The reasons that there is more than one hormone that play a significant role in regulating the balance of Na+ and K+.

Introduction: Na+ and K+ guide the formation of membrane potential and generate an equivalent action potential. The concentration of Na+ and K are tightly regulated in the body fluids of animals. Usually, more than one hormone helps in regulating the balance of Na+ and K+.

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The kidneys are important regulators of blood volume (and thus MAP) and the ionic composition and pH of plasma . The amount of water reabsorbed or lost is hormonally regulated. Both the amount of blood that is filtered (glomerular filtration rate) and the amount of water that is reabsorbed is determined by hormones binding with receptors. In order to understand why the level of any given hormone is elevated or low in the blood, it is necessary to think in terms of homeostasis loops for each hormone, and what the initial disturbance to homeostasis was. In other words “who started it”! What STEROID hormone is elevated by increased activation of the RAS pathway?
The kidneys are important regulators of blood volume (and thus MAP) and the ionic composition and pH of plasma . The amount of water reabsorbed or lost is hormonally regulated. Both the amount of blood that is filtered (glomerular filtration rate) and the amount of water that is reabsorbed is determined by hormones binding with receptors. In order to understand why the level of any given hormone is elevated or low in the blood, it is necessary to think in terms of homeostasis loops for each hormone, and what the initial disturbance to homeostasis was. In other words “who started it”! What NON STEROID hormone is produced at the end (but as part of) of the RAS pathway?
Vasopressin or antidiuretic hormone (ADH) is a peptide hormone synthesized in the a) hypothalamus. This hormone, when present, induces expression of water transport proteins (aquaporins) in the late distal tubule and collecting duct of the kidney to increase water reabsorption. Binding to the receptor triggers an intracellular cyclic adenosine monophosphate (CAMP) pathway. Arrange the following steps of hormone signalling in the proper order by putting 1, 2, 3, etc in the space provided, CAMP activates CAMP-dependent protein kinase (PKA). Recruitment of inactive G-protein made of heterotrimeric subunits which has GDP bound to a-subunit. Conformation change in GPCR. Adenylyl cyclase converts ATP into CAMP. PKA phosphorylates proteins in the cell. A cellular response is seen in the cell. a-subunit with GTP bound activates adenylyl cyclase. Activation of G-protein, thus GDP released an GTP binds to a-subunit. a-subunit of G-protein dissociates from By-dimer. Hormone binding to its…
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