Biology: The Dynamic Science (MindTap Course List)
4th Edition
ISBN: 9781305389892
Author: Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher: Cengage Learning
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Chapter 5, Problem 2ITD
Some cancer cells are insensitive to typical chemotherapy. Research into the mechanisms underlying this insensitivity uncovered an ability by these cells to “pump” the treatment drug out of the cell against its concentration gradient. Additional drugs have been developed that inhibit the pump, thus trapping the chemotherapeutic agent inside to promote cancer cell destruction. The Figure shows what happens when two types of cells are treated with a 3H-labeled anti-cancer drug, paclitaxel.
Two additional drugs, imatinib and nilotinib, are evaluated for their ability to overcome the cancer cells’ ability to “pump out” the chemotherapeutic agent. An asterisk (*) indicates a statistically significant difference from the cells receiving paclitaxel alone. Do the additional drugs seem to the effective in over-coming the pump? Which set of graphs (A or B) best supports your answer? Explain your answer.
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The metabolic pathway below is used for the production of the purine nucleotides adenosine monophosphate (AMP) and guanosine monophosphate (GMP) in eukaryotic cells. Assume each arrow represents a reaction catalyzed by a different enzyme. Using the principles of feedback inhibition, propose a regulatory scheme for this pathway that ensures an adequate supply of both AMP and GMP, and prevents the buildup of Intermediates A through G when supplies of both AMP and GMP are adequate.
QUESTION 27
Label the structures marked A, B, C and explain the role of structure A.
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plasma membrane
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Chapter 5 Solutions
Biology: The Dynamic Science (MindTap Course List)
Ch. 5.1 - Describe the fluid mosaic model for membrane...Ch. 5.1 - Give two examples each of integral proteins and...Ch. 5.2 - What is the difference between passive and active...Ch. 5.2 - Prob. 2SBCh. 5.3 - Prob. 1SBCh. 5.3 - Prob. 2SBCh. 5.4 - Prob. 1SBCh. 5.4 - Prob. 2SBCh. 5.5 - Prob. 1SBCh. 5.5 - Prob. 2SB
Ch. 5 - In the fluid mosaic model: plasma membrane...Ch. 5 - Which of the following statements is false?...Ch. 5 - The freeze-fracture technique demonstrated: a....Ch. 5 - A characteristic of carrier molecules in a primary...Ch. 5 - A driving ion moving through a membrane channel in...Ch. 5 - Phagocytosis illustrates which phenomenon? a....Ch. 5 - Place in order the following events of...Ch. 5 - Prob. 8TYKCh. 5 - Which of the following statements is true for the...Ch. 5 - Using the principle of diffusion, a dialysis...Ch. 5 - Discuss Concepts The bacterium Vibrio cholera...Ch. 5 - Prob. 12TYKCh. 5 - Prob. 13TYKCh. 5 - Prob. 15TYKCh. 5 - Some cancer cells are insensitive to typical...Ch. 5 - Some cancer cells are insensitive to typical...
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