ANATOMY AND PHYSIOLOGY
17th Edition
ISBN: 9781630180928
Author: OpenStax
Publisher: OPENSTAX C
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Chapter 5, Problem 28CTQ
Describe the structure and composition of nails.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
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The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 5 Solutions
ANATOMY AND PHYSIOLOGY
Ch. 5 - The skin consists of two layers and a closely...Ch. 5 - Figure 5.4 If you zoom on the cells at the...Ch. 5 - Figure 5.6 If you zoom on the cells of the stratum...Ch. 5 - This ABC video follows the story of a pair of...Ch. 5 - The papillary layer of the dermis is most closely...Ch. 5 - Langerhans cells are commonly found in the...Ch. 5 - The papillary and reticular layers of the dermis...Ch. 5 - Collagen lends ________ to the skin. elasticity...Ch. 5 - Which of the following is not a function of the...Ch. 5 - In response to stimuli from the sympathetic...
Ch. 5 - The hair matrix contains ________. the hair...Ch. 5 - Eccrine sweat glands ________. are present on hair...Ch. 5 - Sebaceous glands ________. are a type of sweat...Ch. 5 - Similar to the hair, nails grow continuously...Ch. 5 - In humans, exposure of the skin to sunlight is...Ch. 5 - One of the functions of the integumentary system...Ch. 5 - An individual using a sharp knife notices a small...Ch. 5 - As you are walking down the beach, you see a dead,...Ch. 5 - If you cut yourself and bacteria enter the wound,...Ch. 5 - In general, skin cancers ________. are easily...Ch. 5 - Bedsores ________. can be treated with topical...Ch. 5 - An individual has spent too much time sun bathing....Ch. 5 - After a skin injury, the body initiates a...Ch. 5 - Squamous cell carcinomas are the second most...Ch. 5 - What determines the color of skin, and what is the...Ch. 5 - Cells of the epidermis derive from stem cells of...Ch. 5 - Explain the differences between eccrine and...Ch. 5 - Describe the structure and composition of nails.Ch. 5 - Why do people sweat excessively when exercising...Ch. 5 - Explain your skins response to a drop in body core...Ch. 5 - Why do teenagers often experience acne?Ch. 5 - Why do scars look different from surrounding skin?
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