Principles of Human Physiology (6th Edition)
6th Edition
ISBN: 9780134169804
Author: Cindy L. Stanfield
Publisher: PEARSON
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Textbook Question
Chapter 5, Problem 24E
Compare lipophilic and lipophobic chemical messengers with respect to the location of their receptors, their transport in blood, and their general signal transduction mechanisms.
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a. What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent.
b. What will happen to elimination of the drug in the previous question if the system is saturated? explain and show any math involved
If you wanted to reduce the difference between peak and trough levels that occur with repeated administration of a drug, how would you adjust the dose and dose interval without changing the plateau concentration (plateau is the average of peak and trough levels)? Select your answers for both dose and interval. Hint: It may be helpful to think about this problem using an example such as food. How would you eat if you wanted to maintain very steady hunger/satiety levels without changing your total caloric intake?
Options:
A. Dose; Increase dose
B. Dose; Decrease dose
C. Dose; Do not change dose
D. Interval; Increase the interval between doses (give the drug less frequently)
E. Interval; Decrease the interval between doses (give the drug more frequently)
F. Interval; Do not change the interval
What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent. Show the math
Chapter 5 Solutions
Principles of Human Physiology (6th Edition)
Ch. 5.1 - Name the three functional classes of messengers....Ch. 5.1 - Prob. 5.1.2QCCh. 5.1 - Prob. 5.1.3QCCh. 5.2 - How does inhibiting enzymes prevent the sensation...Ch. 5.2 - What negative effects do elevated doses of aspirin...Ch. 5.2 - Prob. 3CTQCh. 5.2 - Prob. 5.2.1QCCh. 5.2 - Prob. 5.2.2QCCh. 5.2 - Prob. 5.2.3QCCh. 5.3 - Prob. 1CTQ
Ch. 5.3 - Prob. 2CTQCh. 5.3 - Prob. 3CTQCh. 5.3 - Where in the target cell are the receptors for...Ch. 5.3 - Name the three categories of membrane-bound...Ch. 5.3 - Name five substances that act as second...Ch. 5 - Prob. 1ECh. 5 -
Epinephrine is a(n)
a. Amino acid.
b....Ch. 5 - Prob. 3ECh. 5 - Prob. 4ECh. 5 - Prob. 5ECh. 5 -
Which of the following is likely to cause an...Ch. 5 -
Which of the following messenger classes bind to...Ch. 5 - Prob. 8ECh. 5 -
G proteins are involved whenever
Binding of...Ch. 5 - Prob. 10ECh. 5 - Prob. 11ECh. 5 - Prob. 12ECh. 5 - Prob. 13ECh. 5 -
When a G protein is activated, it releases a...Ch. 5 -
The enzyme that catalyzes conversion of ATP to...Ch. 5 -
Following activation of the phosphatidylinositol...Ch. 5 - Prob. 17ECh. 5 - Prob. 18ECh. 5 - Cytosolic calcium often exerts its effect by...Ch. 5 - Prob. 20ECh. 5 - Prob. 21ECh. 5 - Prob. 22ECh. 5 - Prob. 23ECh. 5 - Compare lipophilic and lipophobic chemical...Ch. 5 - Prob. 25ECh. 5 -
Describe the cAMP second messenger system,...Ch. 5 - Compare long-distance communication by the nervous...Ch. 5 -
Describe the two types of receptor- mediated...Ch. 5 - Prob. 29ECh. 5 - Prob. 30ECh. 5 - Prob. 31ECh. 5 - Prob. 32ECh. 5 - Prob. 33E
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