Principles of Human Physiology (6th Edition)
Principles of Human Physiology (6th Edition)
6th Edition
ISBN: 9780134169804
Author: Cindy L. Stanfield
Publisher: PEARSON
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Chapter 5, Problem 10E
Summary Introduction

Introduction:

Diacylglycerol (DAG) is an intracellular secondary messenger synthesized from the PIP2 (phosphoinositol-4,5-bisphosphate). The function of DAG is to activate the proteins by phosphorylating them. Cellular growth and differentiation are impacted by the binding of DAG to PKC.

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22. Which of the following mutant proteins is expected to have a dominant negative effect when over-   expressed in normal cells?   a. mutant PI3-kinase that lacks the SH2 domain but retains the kinase function   b. mutant Grb2 protein that cannot bind to RTK   c. mutant RTK that lacks the extracellular domain   d. mutant PDK that has the PH domain but lost the kinase function   e. all of the above
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Principles of Human Physiology (6th Edition)

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