Microbiology with Diseases by Body System & Modified MasteringMicrobiology with Pearson eText -- ValuePack Access Card -- for Microbiology with Diseases by Body System Package
1st Edition
ISBN: 9780133857122
Author: Robert W. Bauman Ph.D.
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Textbook Question
Chapter 5, Problem 20CT
In addition to extremes in temperature and pH, other chemical and physical agents denature proteins. These agents include ionizing radiation, alcohol, enzymes, and heavy-metal ions. For example, the first antimicrobial drug, arsphenamine, contained the heavy metal arsenic and was used to inhibit the enzymes of the bacterium Treponema pallidum, the causative agent of syphilis. Given that both human and bacterial enzymes are denatured by heavy metals, how was arsphenamine used to treat syphilis without poisoning the patient? Why is syphilis no longer treated with arsenic-containing compounds?
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
An industrial waste contains an inhibitory compound for microorganisms. You
have determined that biological treatment would be the best process option if
this inhibitory compound was not present. Identify and discuss your approach
for handling this problem.
For each of the following examples, indicate whether the drug is acting on physical process, chemical process or enzymatic system (your answer should be only; Physical, Chemical or Enzymatic).
A. A drug is used as an antidote in lead poisoning and acts by binding to lead particles in body (chelation therapy).
B. A drug acts to reduce flatulence and acts by reducing the surface tension of intestinal gas bubbles in the GI tract (e.g. Simethicone).
C. A drug competes with alpha-glucosidase in intestine to reduce glucose conversion from disaccharides (e.g. Acarbose).
A culture medium consisting of known amounts of glucose, NaCl, and ammonium and potassium phosphate would be an example of:
Chapter 5 Solutions
Microbiology with Diseases by Body System & Modified MasteringMicrobiology with Pearson eText -- ValuePack Access Card -- for Microbiology with Diseases by Body System Package
Ch. 5 - How can oxidation take place in an anaerobic...Ch. 5 - Why do electrons carried by NADH allow for...Ch. 5 - Why does catabolism of amino acids for energy...Ch. 5 - An uninformed student describes the Calvin-Benson...Ch. 5 - Prob. 5TMWCh. 5 - Why is feedback inhibition necessary for...Ch. 5 - Breaks a large molecule into smaller ones a....Ch. 5 - Includes dehydration synthesis reactions a....Ch. 5 - Prob. 3MCCh. 5 - Prob. 4MC
Ch. 5 - Involves the production of cell membrane...Ch. 5 - Includes hydrolytic reactions a. anabolism only b....Ch. 5 - Includes metabolism a. anabolism only b. both...Ch. 5 - Prob. 8MCCh. 5 - A reduced molecule _________. a. has gained...Ch. 5 - Prob. 10MCCh. 5 - Coenzymes are ________. a. types of apoenzymes b....Ch. 5 - Which of the following statements best describes...Ch. 5 - Which of the following does not affect the...Ch. 5 - Most oxidation reactions in bacteria involve the...Ch. 5 - Under ideal conditions, the fermentation of one...Ch. 5 - Under ideal conditions, the complete aerobic...Ch. 5 - Which of the following statements about the...Ch. 5 - Reactions involved in the light-independent...Ch. 5 - The glycolysis pathway is basically __________. a....Ch. 5 - A major difference between anaerobic respiration...Ch. 5 - 1. _______ Occurs when energy from a compound...Ch. 5 - Fill in the Blanks 1. The final electron acceptor...Ch. 5 - Fill in the Blanks 2. Two ATP molecules are used...Ch. 5 - Fill in the Blanks 3. The initial catabolism of...Ch. 5 - Fill in the Blanks 4. ________ is a cyclic series...Ch. 5 - Fill in the Blanks 5. The final electron acceptor...Ch. 5 - Fill in the Blanks 6. Three common inorganic...Ch. 5 - Fill in the Blanks 7. Anaerobic respiration...Ch. 5 - Fill in the Blanks 8. Complete the following...Ch. 5 - Prob. 9FIBCh. 5 - Fill in the Blanks 10 The main coenzymes that...Ch. 5 - VISUALIZE IT! 1 Label the mitochondrion to...Ch. 5 - Label the diagram below to indicate acetyl-CoA,...Ch. 5 - Examine the biosynthetic pathway for the...Ch. 5 - Prob. 1SACh. 5 - Why we enzymes necessary for anabolic reactions to...Ch. 5 - How do organisms control the rate of metabolic...Ch. 5 - How does a nor-competitive inhibitor at a single...Ch. 5 - Explain the mechanism of negative feedback with...Ch. 5 - Facultative anaerobes can live under either...Ch. 5 - How does oxidation of a molecule occur without...Ch. 5 - List at least four groups of microorganisms that...Ch. 5 - Why do we breathe oxygen and give of carbon...Ch. 5 - Why do cyanobacteria and algae take in carbon...Ch. 5 - What happens to the carbon atoms in sugar...Ch. 5 - How do yeast cells make alcohol and cause bread to...Ch. 5 - Where specifically does the most significant...Ch. 5 - Why are vitamins essential metabolic factors for...Ch. 5 - A laboratory scientist notices that a cer1ain...Ch. 5 - Arsenic is a poison that exists in two states in...Ch. 5 - Explain why an excess of all three of the amino...Ch. 5 - Why might an organism that uses glycolysis and the...Ch. 5 - Describe how bacterial fermentation causes milk to...Ch. 5 - Giardia intestinalis and Entamoeba histolytica are...Ch. 5 - Two cultures of a facultative anaerobe are grown...Ch. 5 - What is the maximum number of molecules of ATP...Ch. 5 - In terms of its effects on human metabolism, why...Ch. 5 - Cyanide is a potent poison because it irreversibly...Ch. 5 - How are photophosphorylation and oxidative...Ch. 5 - Members of the pathogenic bacterial genus...Ch. 5 - Compare and contrast aerobic respiration,...Ch. 5 - Scientists estimate that up to one-third of Earths...Ch. 5 - A young student was troubled by the idea that a...Ch. 5 - If a bacterium uses beta-oxidation to catabolize a...Ch. 5 - Some desert rodents rarely have water to drink....Ch. 5 - Prob. 17CTCh. 5 - We have examined the total ATP, NADH, and FADH2...Ch. 5 - Explain why hyperthermophiles do not cause disease...Ch. 5 - In addition to extremes in temperature and pH,...Ch. 5 - Figure 5.18b illustrates events in aerobic...Ch. 5 - Suppose you could insert a tiny pH probe into the...Ch. 5 - Even though Pseudomonas aeruginosa and...Ch. 5 - Photosynthetic organisms are rarely pathogenic....Ch. 5 - Prob. 25CTCh. 5 - A scientist moves a green plant grown in sunlight...Ch. 5 - What class of enzyme is involved in amination...Ch. 5 - Using the following terms, fill in the following...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- What class of macromolecule is antivenin? Either: Lipid, Carbohydrate, Nucleic acid, Protein Context: Although our local poison control center had no knowledge of caterpillar envenomation, they facilitated contact with clinicians from Brazil, who recommended immediate administration of a locally produced antivenin. We made arrangements to obtain the antivenin from Brazil, which took 48 hours to arrive.arrow_forwardThe Cavity Ring-Down Spectroscopy (CRDS) technique offers greater sensitivity compared to other conventional spectroscopy techniques. Explain the underlying mechanism of this.arrow_forwardWhich of the following stains highlights iron deposits in cells? Question 10 options: A) Prussian blue B) LAP C) TRAP D) alpha-naphthyl butyrate esterasearrow_forward
- categorize the following into reversible or irreversible (competitive or non-competitive) inhibitors. No explanation is required, just list the name of the inhibitor. a) Penicillin b) Cyanide c) Aspirin d) Tipranavirarrow_forwardA thermophillic bacterium was isolated from a hot spring at Perak. Bernager Lee is a researcher interested to study its amylase gene. Before the gene could be cloned for further work, the genome of this bacterium should first be extracted. He plans to use the conventional method utilizing Phenol, Chloroform and Isoamyl alcohol. Discuss the functions of these three chemicals in this procedure.arrow_forwardIn detail, why 70% Alcohol is better than 100% Alcohol (as an antiseptic) to control the growth of bacteria?arrow_forward
- There are six major groups of enzymes. The categories are based on the types of reactions that they catalyze. What type of enzyme converts a molecule to another structure with the same formula through breaking bonds and forming new bonds. A) Lyases B) Transferases C) Hydrolases D) Isomerases E) Ligasesarrow_forwardWhich of the following is true about enzymes. a) Enzymes are catalysts and they increase the rate of a reaction while they are not altered by the reaction. b) Enzymes are proteins that can be denatured by changes in pH or temperature. c) Enzymes are highly specific for the substrates they react with and catalyze only one or a limited set of possible reactions with those substrates. d) All of these are true about enzymes e) None of these are true about enzymesarrow_forwardSince the development of the calcium chloride transformation procedure, other procedures have been developed. One is called electroporation. Using your textbook or other sources, describe this procedure for transformation.arrow_forward
- The authors in the abstract given above describe the mechanism for the activation of metallothionein (MTF) that results in the detoxification of heavy metals. Use a diagram to illustrate and describe the cascade of events that occur as proposed by the authors.arrow_forwardDescribe in short the process of size exclusion chromatography (molecular exclusion chromatography)arrow_forward. Based on what you know about enzyme inhibition, classify the following examples as irreversible, competitive, or noncompetitive enzyme inhibition. A) competitive B) noncompetitive C) irreversible 1) Diisopropyl fluorophosphate binds to acetylcholinesterase and permanently inactivates the enzyme. Paralysis results. 2) A drug binds to the active site of an enzyme but disassociates and leaves the enzyme active. 3) A toxin binds to the surface of an enzyme. The enzyme then binds the substrate, but no product is produced. The toxin may disassociate and the enzyme will become active again. 4) Vitamin K is a coenzyme involved in blood clotting. An anticoagulant drug binds at the site of vitamin K bonding, blocking vitamin K binding and preventing clotting. Clotting resumes after the patient stops taking the drug. 5) Aspirin binds to prostaglandin synthetase and permanently stops its ability to produce prostaglandin.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Enzyme Kinetics; Author: MIT OpenCourseWare;https://www.youtube.com/watch?v=FXWZr3mscUo;License: Standard Youtube License