The protein that has higher affinity for ligand X. Whether it is protein A or B. Introduction: Proteins are the biomolecules that are composed of amino acids. Proteins are the end products of gene expression. They are the building blocks of the body. The function of protein depends on the interaction with other molecules. A compound which is bound reversibly to a protein is known as a ligand.

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Answer 1

Question

Chapter 5, Problem 1P

Summary Introduction

To determine: The protein that has higher affinity for ligand X. Whether it is protein A or B.

Introduction:

Proteins are the biomolecules that are composed of amino acids. Proteins are the end products of gene expression. They are the building blocks of the body. The function of protein depends on the interaction with other molecules. A compound which is bound reversibly to a protein is known as a ligand.

Expert Solution

Explanation of Solution

Dissociation constant (K_d) explains the binding of a ligand to its particular receptor. In molar concentration, dissociation constant matches with the concentration of ligands. The smaller the K_d, more strongly the ligand is bound to its receptors and high Kd indicates less affinity. Therefore, protein B has smaller K_d than protein A, which is 10^-9. Hence, protein B has higher affinity for ligand X.

Summary Introduction

To determine: The conversion of K_d into K_a (association constant) for protein A and protein B.

Introduction:

K_d denotes the dissociation constant, that describes how a ligand bound to its receptor. Small K_d indicates higher affinity, while high K_d indicates less affinity. K_a is just the inverse of the K_d. It is also called association or binding constant. They are involved in unbinding of the ligand and receptors.

Expert Solution

Explanation of Solution

Dissociation constant tells the binding of a ligand to its receptor. Whereas association constant tells the unbinding of a ligand and receptors. So, they are just opposite to each other. As K_a is the inverse of K_d, the protein A has K_a of 10⁶_M^-1 and protein B has K_a of 10⁹_M^-1.

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Answer 2

Question

Chapter 5, Problem 1P

Summary Introduction

To determine: The protein that has higher affinity for ligand X. Whether it is protein A or B.

Introduction:

Proteins are the biomolecules that are composed of amino acids. Proteins are the end products of gene expression. They are the building blocks of the body. The function of protein depends on the interaction with other molecules. A compound which is bound reversibly to a protein is known as a ligand.

Expert Solution

Explanation of Solution

Dissociation constant (K_d) explains the binding of a ligand to its particular receptor. In molar concentration, dissociation constant matches with the concentration of ligands. The smaller the K_d, more strongly the ligand is bound to its receptors and high Kd indicates less affinity. Therefore, protein B has smaller K_d than protein A, which is 10^-9. Hence, protein B has higher affinity for ligand X.

Summary Introduction

To determine: The conversion of K_d into K_a (association constant) for protein A and protein B.

Introduction:

K_d denotes the dissociation constant, that describes how a ligand bound to its receptor. Small K_d indicates higher affinity, while high K_d indicates less affinity. K_a is just the inverse of the K_d. It is also called association or binding constant. They are involved in unbinding of the ligand and receptors.

Expert Solution

Explanation of Solution

Dissociation constant tells the binding of a ligand to its receptor. Whereas association constant tells the unbinding of a ligand and receptors. So, they are just opposite to each other. As K_a is the inverse of K_d, the protein A has K_a of 10⁶_M^-1 and protein B has K_a of 10⁹_M^-1.

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Answer 3

Question

Chapter 5, Problem 1P

Summary Introduction

To determine: The protein that has higher affinity for ligand X. Whether it is protein A or B.

Introduction:

Proteins are the biomolecules that are composed of amino acids. Proteins are the end products of gene expression. They are the building blocks of the body. The function of protein depends on the interaction with other molecules. A compound which is bound reversibly to a protein is known as a ligand.

Expert Solution

Explanation of Solution

Dissociation constant (K_d) explains the binding of a ligand to its particular receptor. In molar concentration, dissociation constant matches with the concentration of ligands. The smaller the K_d, more strongly the ligand is bound to its receptors and high Kd indicates less affinity. Therefore, protein B has smaller K_d than protein A, which is 10^-9. Hence, protein B has higher affinity for ligand X.

Summary Introduction

To determine: The conversion of K_d into K_a (association constant) for protein A and protein B.

Introduction:

K_d denotes the dissociation constant, that describes how a ligand bound to its receptor. Small K_d indicates higher affinity, while high K_d indicates less affinity. K_a is just the inverse of the K_d. It is also called association or binding constant. They are involved in unbinding of the ligand and receptors.

Expert Solution

Explanation of Solution

Dissociation constant tells the binding of a ligand to its receptor. Whereas association constant tells the unbinding of a ligand and receptors. So, they are just opposite to each other. As K_a is the inverse of K_d, the protein A has K_a of 10⁶_M^-1 and protein B has K_a of 10⁹_M^-1.

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Answer 4

Question

Chapter 5, Problem 1P

Summary Introduction

To determine: The protein that has higher affinity for ligand X. Whether it is protein A or B.

Introduction:

Proteins are the biomolecules that are composed of amino acids. Proteins are the end products of gene expression. They are the building blocks of the body. The function of protein depends on the interaction with other molecules. A compound which is bound reversibly to a protein is known as a ligand.

Expert Solution

Explanation of Solution

Dissociation constant (K_d) explains the binding of a ligand to its particular receptor. In molar concentration, dissociation constant matches with the concentration of ligands. The smaller the K_d, more strongly the ligand is bound to its receptors and high Kd indicates less affinity. Therefore, protein B has smaller K_d than protein A, which is 10^-9. Hence, protein B has higher affinity for ligand X.

Summary Introduction

To determine: The conversion of K_d into K_a (association constant) for protein A and protein B.

Introduction:

K_d denotes the dissociation constant, that describes how a ligand bound to its receptor. Small K_d indicates higher affinity, while high K_d indicates less affinity. K_a is just the inverse of the K_d. It is also called association or binding constant. They are involved in unbinding of the ligand and receptors.

Expert Solution

Explanation of Solution

Dissociation constant tells the binding of a ligand to its receptor. Whereas association constant tells the unbinding of a ligand and receptors. So, they are just opposite to each other. As K_a is the inverse of K_d, the protein A has K_a of 10⁶_M^-1 and protein B has K_a of 10⁹_M^-1.

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Answer 5

Chapter 5, Problem 1P

Summary Introduction

To determine: The protein that has higher affinity for ligand X. Whether it is protein A or B.

Introduction:

Proteins are the biomolecules that are composed of amino acids. Proteins are the end products of gene expression. They are the building blocks of the body. The function of protein depends on the interaction with other molecules. A compound which is bound reversibly to a protein is known as a ligand.

Expert Solution

Explanation of Solution

Dissociation constant (K_d) explains the binding of a ligand to its particular receptor. In molar concentration, dissociation constant matches with the concentration of ligands. The smaller the K_d, more strongly the ligand is bound to its receptors and high Kd indicates less affinity. Therefore, protein B has smaller K_d than protein A, which is 10^-9. Hence, protein B has higher affinity for ligand X.

Summary Introduction

To determine: The conversion of K_d into K_a (association constant) for protein A and protein B.

Introduction:

K_d denotes the dissociation constant, that describes how a ligand bound to its receptor. Small K_d indicates higher affinity, while high K_d indicates less affinity. K_a is just the inverse of the K_d. It is also called association or binding constant. They are involved in unbinding of the ligand and receptors.

Expert Solution

Explanation of Solution

Dissociation constant tells the binding of a ligand to its receptor. Whereas association constant tells the unbinding of a ligand and receptors. So, they are just opposite to each other. As K_a is the inverse of K_d, the protein A has K_a of 10⁶_M^-1 and protein B has K_a of 10⁹_M^-1.

Answer 6

Chapter 5, Problem 1P

Summary Introduction

To determine: The protein that has higher affinity for ligand X. Whether it is protein A or B.

Introduction:

Proteins are the biomolecules that are composed of amino acids. Proteins are the end products of gene expression. They are the building blocks of the body. The function of protein depends on the interaction with other molecules. A compound which is bound reversibly to a protein is known as a ligand.

Expert Solution

Explanation of Solution

Dissociation constant (K_d) explains the binding of a ligand to its particular receptor. In molar concentration, dissociation constant matches with the concentration of ligands. The smaller the K_d, more strongly the ligand is bound to its receptors and high Kd indicates less affinity. Therefore, protein B has smaller K_d than protein A, which is 10^-9. Hence, protein B has higher affinity for ligand X.

Answer 7

Chapter 5, Problem 1P

Summary Introduction

To determine: The protein that has higher affinity for ligand X. Whether it is protein A or B.

Introduction:

Proteins are the biomolecules that are composed of amino acids. Proteins are the end products of gene expression. They are the building blocks of the body. The function of protein depends on the interaction with other molecules. A compound which is bound reversibly to a protein is known as a ligand.

Answer 8

Expert Solution

Explanation of Solution

Dissociation constant (K_d) explains the binding of a ligand to its particular receptor. In molar concentration, dissociation constant matches with the concentration of ligands. The smaller the K_d, more strongly the ligand is bound to its receptors and high Kd indicates less affinity. Therefore, protein B has smaller K_d than protein A, which is 10^-9. Hence, protein B has higher affinity for ligand X.

Answer 9

Expert Solution

Answer 10

Expert Solution

Answer 11

Expert Solution

Answer 12

Summary Introduction

To determine: The conversion of K_d into K_a (association constant) for protein A and protein B.

Introduction:

K_d denotes the dissociation constant, that describes how a ligand bound to its receptor. Small K_d indicates higher affinity, while high K_d indicates less affinity. K_a is just the inverse of the K_d. It is also called association or binding constant. They are involved in unbinding of the ligand and receptors.

Expert Solution

Explanation of Solution

Dissociation constant tells the binding of a ligand to its receptor. Whereas association constant tells the unbinding of a ligand and receptors. So, they are just opposite to each other. As K_a is the inverse of K_d, the protein A has K_a of 10⁶_M^-1 and protein B has K_a of 10⁹_M^-1.

Answer 13

Summary Introduction

To determine: The conversion of K_d into K_a (association constant) for protein A and protein B.

Introduction:

K_d denotes the dissociation constant, that describes how a ligand bound to its receptor. Small K_d indicates higher affinity, while high K_d indicates less affinity. K_a is just the inverse of the K_d. It is also called association or binding constant. They are involved in unbinding of the ligand and receptors.

Answer 14

Expert Solution

Explanation of Solution

Dissociation constant tells the binding of a ligand to its receptor. Whereas association constant tells the unbinding of a ligand and receptors. So, they are just opposite to each other. As K_a is the inverse of K_d, the protein A has K_a of 10⁶_M^-1 and protein B has K_a of 10⁹_M^-1.