The hemoglobin variant least likely to cause pathological symptoms. Introduction: Hemoglobin is the blood protein that carries the oxygen molecule. It is composed of four heme groups which surround the globin group. Heme groups possess iron and provides a red color to the blood cells. Hemoglobin is present in the tetrameric form that consist 2 dimers ( α, β dimers ) that binds to the oxygen molecule. There are almost 500 naurally occurring variants of Hb including HbS, Hb Memphis, Hb Bibba, Hb Philly Hb Milwaukee, and Hb Providence.

Question

Consider the reaction. kp S P kg What effects are produced by an enzyme on the general reaction? AG for the reaction increases. The rate constant for the reverse reaction (kr) increases. The reaction equilibrium is shifted toward the products. The concentration of the reactants is increased. The activation energy for the reaction is lowered. The formation of the transition state is promoted.

Answer 1

Question

Chapter 5, Problem 9P

(a)

Summary Introduction

To determine: The hemoglobin variant least likely to cause pathological symptoms.

Introduction:

Hemoglobin is the blood protein that carries the oxygen molecule. It is composed of four heme groups which surround the globin group. Heme groups possess iron and provides a red color to the blood cells. Hemoglobin is present in the tetrameric form that consist 2 dimers ( α, β dimers ) that binds to the oxygen molecule. There are almost 500 naurally occurring variants of Hb including HbS, Hb Memphis, Hb Bibba, Hb Philly Hb Milwaukee, and Hb Providence.

(b)

Summary Introduction

To determine: The variant most likely to show pI values different from that HbA on an isoelectric focusing gel.

Introduction:

Hemoglobin is the blood protein that carries the oxygen molecule. It is composed of four heme groups which surround the globin group. Heme groups possess iron and provides a red color to the blood cells. Hemoglobin is present in the tetrameric form that consist 2 dimers ( α, β dimers ) that binds to the oxygen molecule. There are almost 500 naurally occurring variants of Hb including HbS, Hb Memphis, Hb Bibba, Hb Philly Hb Milwaukee, and Hb Providence.

(c)

Summary Introduction

To determine: The variant most likely to show a decrease in BPG binding and an increase in the overall affinity of the hemoglobin for oxygen

Introduction:

Hemoglobin is the blood protein that carries the oxygen molecule. It is composed of four heme groups which surround the globin group. Heme groups possess iron and provides a red color to the blood cells. Hemoglobin is present in the tetrameric form that consist 2 dimers ( α, β dimers ) that binds to the oxygen molecule. There are almost 500 naurally occurring variants of Hb including HbS, Hb Memphis, Hb Bibba, Hb Philly Hb Milwaukee, and Hb Providence.

Expert Solution & Answer

Trending nowThis is a popular solution!

See solution

Check out sample textbook solution

Students have asked these similar questions

Consider the reaction. kp S P kg What effects are produced by an enzyme on the general reaction? AG for the reaction increases. The rate constant for the reverse reaction (kr) increases. The reaction equilibrium is shifted toward the products. The concentration of the reactants is increased. The activation energy for the reaction is lowered. The formation of the transition state is promoted.

The graph displays the activities of wild-type and several mutated forms of subtilisin on a logarithmic scale. The mutations are identified as: • The first letter is the one-letter abbreviation for the amino acid being altered. • The number identifies the position of the residue in the primary structure. ⚫ The second letter is the one-letter abbreviation for the amino acid replacing the original one. • Uncat. refers to the estimated rate for the uncatalyzed reaction. Log₁(S-1) Wild type S221A H64A -5 D32A S221A H64A D32A -10 Uncat. How would the activity of a reaction catalyzed by a version of subtilisin with all three residues in the catalytic triad mutated compare to the activity of the uncatalyzed reaction? It would have more activity, because the reaction catalyzed by the triple mutant is approximately three-fold faster than the uncatalyzed reaction. It would have less activity, because the reaction catalyzed by the triple mutant is approximately 1000-fold slower than the…

B Substrate Product AL Product Substrate Reaction progress- Reaction progress- omplete the passage describing the two reactions. In reaction A, the stability of the substrate is (AG) of the reaction is positive, Incorrect Answer greater than the stability of the product. The free-energy change Incorrect Answer so the reaction is considered In reaction B, the stability of the substrate is (AG) of the reaction is less than Incorrect Answer endergonic and Incorrect Answer not spontaneous. Incorrect Answer the stability of the product. The free-energy change negative, so the reaction is considered Incorrect Answer exergonic and spontaneous. Incorrect Answer Incorrect Answer