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Concept explainers
Interpretation:
The chiral center in the molecular model of thalidomide is to be identified and its absolute configuration as R or S is to be determined.
Concept introduction:
When a tetrahedral carbon atom is connected to four different atoms or groups, then that carbon is called a chiral carbon or chiral center.
The absolute configuration is the three-dimensional spatial arrangement of substituents attached to a chiral center.
The Cahn-Ingold-Prelog rule system lists the substituents bonded to the chiral center in the order of decreasing atomic number. A higher atomic number has a higher priority over a lower atomic number for the substituent.
When there are two identical atoms directly attached to the chirality center, then they are ranked on the basis of the
If an atom has multiple bonds, it is considered to be replicated as a substituent on that atom.
If isotopes are present, they are ranked on the basis of their
The molecule is oriented such that the lowest ranked group points away from the observer.
If the remaining three groups in order of decreasing priority trace a clockwise path, the configuration is R.
If the remaining three groups in order of decreasing priority trace a counter clockwise path, the configuration is S.
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Chapter 4 Solutions
ORGANIC CHEMISTRY (LOOSELEAF)-PACKAGE
- Nucleophilic Aromatic Substitution: What is the product of the reaction? *see imagearrow_forwardShow the correct sequence to connect the reagent to product. * see imagearrow_forwardThe answer here says that F and K have a singlet and a doublet. The singlet and doublet are referring to the H's 1 carbon away from the carbon attached to the OH. Why don't the H's two carbons away, the ones on the cyclohexane ring, cause more peaks on the signal?arrow_forward
- Draw the Birch Reduction for this aromatic compound and include electron withdrawing groups and electron donating groups. *See attachedarrow_forwardShow the correct sequence to connect the reagent to product. * see imagearrow_forwardBlocking Group are use to put 2 large sterically repulsive group ortho. Show the correct sequence toconnect the reagent to product with the highest yield possible. * see imagearrow_forward
- Elimination-Addition: What molecule was determined to be an intermediate based on a “trapping experiment”? *please solve and see imagearrow_forwardShow the correct sequence to connect the reagent to product. * see imagearrow_forwardPredict the final product. If 2 products are made, list which should be “major” and “minor”. **see attachedarrow_forward
- Organic Chemistry: A Guided InquiryChemistryISBN:9780618974122Author:Andrei StraumanisPublisher:Cengage Learning
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