Biological Science, Loose-leaf Edition (7th Edition)
7th Edition
ISBN: 9780135272800
Author: Scott Freeman, Kim Quillin, Lizabeth Allison, Michael Black, Greg Podgorski, Emily Taylor, Jeff Carmichael
Publisher: PEARSON
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Chapter 48, Problem 16PIAT
Summary Introduction
To review:
The additional information required to decide whether diabetic parents should intentionally infect their child with intestinal worms.
Introduction:
Heligmosomoides polygyrus (Hp) is a naturally occurring roundworm of rodents. It inhabits the intestinal tract of rodents. The studies revealed that the percentage of developing diabetes type 1 is significantly decreased in mice prone to disease after Hp infection.
Based on this evidence, it has to be decided whether diabetic patients can intentionally infect their children with the worms to decrease the risk of diabetes. Although the intestinal worm infection may decrease the risk of diabetes, it can cause potential side-effects as well.
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19. On the diagram below
a. Label the three pictures as: DNA; polypeptide; or RNA.
b. Label the arrows as: translation or transcription/RNA processing.
c. Add the following details to the diagram.
Promoter region
TATA box
Transcription start site
Transcription terminator
Intron (A,B,C,D)
Exons (1,2,3,4,5)
Splice sites
5' cap
5' UTR (untranslated region)
3' poly A tail
3' UTR (untranslated region)
Translational start (AUG)
Translational stop (UGA, UAG, or UAA)
N and C ends of polypeptide
0000
Match the letter labels in the figure below to the terms. Some letter
labels are not used.
MNNNNNNIN
M
C
B
A
M
D
F
E
H
K
G
8
The diagram below illustrates a quorum sensing pathway from Staphylococcus aureus. Please answer the following questions.
1. Autoinduction is part of the quorum sensing system. Which promoter (P2 or P3) is critical for autoinduction?
2)This staphylococcus aureus grows on human wounds, causing severe infections. You would like to start a clinical trial to treat these wound infections. Please describe:
a) What molecule do you recommend for the trial. Why?
b) Your trial requires that Staphylococcus aureus be isolated from the wound and submitted to genome sequencing before admittance. Why? What are you testing for?
3) If a mutation arises where the Promoter P3 is constitutively active, how would that influence sensitivity to AIP? Please explain your rationale.
4) This pathway is sensitive to bacterial cell density. Describe two separate mutation that would render the pathway active independent of cell density. Briefly explain your rationale.
Mutation 1
Mutation 2
Chapter 48 Solutions
Biological Science, Loose-leaf Edition (7th Edition)
Ch. 48 - Prob. 2TYKCh. 48 - Prob. 3TYKCh. 48 - 4. What is one of the differences between CD4+ and...Ch. 48 - Prob. 5TYUCh. 48 - What steps are required for most B cells to become...Ch. 48 - Prob. 9TYPSSCh. 48 - Propose a hypothesis to explain how self-reactive...Ch. 48 - Prob. 11PIATCh. 48 - 13. Pattern recognition receptors have been...Ch. 48 - Prob. 14PIAT
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