Microbiology: A Systems Approach
4th Edition
ISBN: 9780073402437
Author: Marjorie Kelly Cowan Professor
Publisher: McGraw-Hill Education
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Chapter 4.6, Problem 16AYP
Define a species in terms of bacteria.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
MAKE SURE ANSWERS HAVE UNITS if appropriate.
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 4 Solutions
Microbiology: A Systems Approach
Ch. 4.1 - List the structures all bacteria possess.Ch. 4.1 - Identify at least four structures that some, but...Ch. 4.1 - Prob. 3AYPCh. 4.1 - Prob. 4AYPCh. 4.1 - Provide at least four terms to describe bacterial...Ch. 4.2 - Describe the structure and function of five...Ch. 4.2 - Prob. 7AYPCh. 4.3 - Prob. 2CFCh. 4.3 - Prob. 8AYPCh. 4.3 - Prob. 9AYP
Ch. 4.3 - Prob. 10AYPCh. 4.4 - Prob. 11AYPCh. 4.4 - Prob. 12AYPCh. 4.5 - List some differences between archaea and...Ch. 4.6 - Differentiate between Bergeys Manual of Systematic...Ch. 4.6 - Prob. 15AYPCh. 4.6 - Define a species in terms of bacteria.Ch. 4.6 - Prob. 2CFCh. 4 - Prob. 1CFCh. 4 - Which of the following is not found in all...Ch. 4 - Pili are tubular shafts in ____ bacteria that...Ch. 4 - Prob. 3MCQCh. 4 - Which of the following is a primary bacterial cell...Ch. 4 - Which of the following is present in both...Ch. 4 - Darkly stained granules are concentrated crystals...Ch. 4 - Bacterial endospores usually function in a....Ch. 4 - A bacterial arrangement in packets of eight cells...Ch. 4 - Prob. 9MCQCh. 4 - Prob. 10MCQCh. 4 - Prob. 11TFCh. 4 - A research microbiologist looking at evolutionary...Ch. 4 - Nanobes may or may not actually be bacteria.Ch. 4 - Both bacteria and archaea used to be known as...Ch. 4 - Prob. 15TFCh. 4 - Define the term ubiquitous and explain whether...Ch. 4 - Prob. 2CTQCh. 4 - Quorum sensing is a process used by many bacteria...Ch. 4 - Prob. 4CTQCh. 4 - Prob. 5CTQCh. 4 - Based upon your knowledge of cell wall structure,...Ch. 4 - Provide evidence in support of or refuting the...Ch. 4 - a.Describe the characteristics of an...Ch. 4 - Prob. 9CTQCh. 4 - Prob. 10CTQCh. 4 - Prob. 1CCCh. 4 - Prob. 2CCCh. 4 - Prob. 1VCCh. 4 - From chapter 1, figure 1.14. Study this figure....Ch. 4 - Prob. 1CM
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