The way by which structure of the nucleus affect how information stored in DNA is used by the cell. Concept introduction: Cells are the fundamental unit of life. They are modified in different ways to carry out various functions. Prokaryotes are single-celled organisms and eukaryotes are mostly multicellular organisms. Protists and fungi are eukaryotes that are single-celled. Plants and animals are the eukaryotes that are multi-celled organisms.

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.

Answer 1

Question

Chapter 4.4, Problem 1C

Summary Introduction

To determine: The way by which structure of the nucleus affect how information stored in DNA is used by the cell.

Concept introduction: Cells are the fundamental unit of life. They are modified in different ways to carry out various functions. Prokaryotes are single-celled organisms and eukaryotes are mostly multicellular organisms. Protists and fungi are eukaryotes that are single-celled. Plants and animals are the eukaryotes that are multi-celled organisms.

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.

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