Campbell Biology, Books a la Carte Plus Mastering Biology with eText -- Access Card Package (10th Edition)
Campbell Biology, Books a la Carte Plus Mastering Biology with eText -- Access Card Package (10th Edition)
10th Edition
ISBN: 9780133922851
Author: Jane B. Reece, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Robert B. Jackson
Publisher: PEARSON
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Chapter 41.5, Problem 3CC
Summary Introduction

To explain: The effect of insulinomas on blood glucose levels and liver functions.

Introduction:

Insulinomas are cancerous insulin-producing beta cells of pancreatic islets of Langerhans. These tumors lack response to feedback mechanisms and secret insulin even when there is a low blood glucose level in the body.

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WA 82. Regulation of cellular metabolism by insulin requires activation of the insulin-receptor substrate protein-1 (IRS1). Some individuals who have type 2 diabetes mellitus have mutations in the IRS1 gene. Which of the following normal steps in insulin signaling is most likely to be impaired by these mutations? A) Cleavage of IRS1 by the insulin receptor B) Phosphorylation of IRS1 by the insulin receptor C) Production of inositol 1,4,5-trisphosphate by IRS1 D) Stimulation of a G protein by IRS1 E) Synthesis of diacylglycerol by IRS1
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. What would be the effect of a mutation in the gene for PTP1B (protein tyrosine phosphatase 1B) that inactivated the enzyme in a person who has type 2 diabetes?

Chapter 41 Solutions

Campbell Biology, Books a la Carte Plus Mastering Biology with eText -- Access Card Package (10th Edition)

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