Campbell Biology In Focus
2nd Edition
ISBN: 9780134203072
Author: Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Jane B. Reece
Publisher: PEARSON
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Chapter 41.2, Problem 2CC
How is a food chain different from a food web?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 41 Solutions
Campbell Biology In Focus
Ch. 41.1 - Explain how interspecific competition, predation,...Ch. 41.1 - According to the principle of competitive...Ch. 41.1 - MAKE CONNECTIONS Figure 22.13 illustrates how a...Ch. 41.2 - What two components contribute to species...Ch. 41.2 - How is a food chain different from a food web?Ch. 41.2 - WHAT IF? Consider a grassland with five trophic...Ch. 41.2 - MAKE CONNECTIONS Rising atmospheric CO2 levels...Ch. 41.3 - Why do high and low levels of disturbance usually...Ch. 41.3 - During succession, how might the early species...Ch. 41.3 - WHAT IF? Most prairies experience regular fires,...
Ch. 41.4 - Describe two hypotheses that explain why species...Ch. 41.4 - Describe how an islands size and distance from the...Ch. 41.4 - WHAT IF? Based on MacArthur and Wilsons island...Ch. 41.5 - What are pathogens?Ch. 41.5 - Prob. 2CCCh. 41 - The feeding relationships among the species in a...Ch. 41 - Prob. 2TYUCh. 41 - Prob. 3TYUCh. 41 - Community 1 contains 100 individuals distributed...Ch. 41 - Prob. 5TYUCh. 41 - SCIENTIFIC INQUIRY An ecologist studying plants in...Ch. 41 - FOCUS ON EVOLUTION Explain why adaptations of...Ch. 41 - FOCUS ON INFORMATION In Bateslan mimicry, a...Ch. 41 - SYNTHESIZE YOUR KNOWLEDGE Describe two types of...
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