Laboratory Manual for Human Anatomy & Physiology Main Version
4th Edition
ISBN: 9781260159110
Author: Terry Martin
Publisher: Mcgraw-hill Higher Education (us)
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Chapter 41, Problem 2.4A
Summary Introduction
To fill:
The correct term in the given blank.
Introduction:
Blood is composed of 45 % of blood cells and the remaining 55 % is the plasma. There are three types of blood cells; Red blood cells, white blood cells and platelets.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 41 Solutions
Laboratory Manual for Human Anatomy & Physiology Main Version
Ch. 41 - Prob. 1PLCh. 41 - Which of the following is among the agranulocytes?...Ch. 41 - Prob. 3PLCh. 41 - Prob. 4PLCh. 41 - Prob. 5PLCh. 41 - Prob. 6PLCh. 41 - Prob. 7PLCh. 41 - Erythrocytes we also called granulocytes because...Ch. 41 - Complete the following statements: Red blood cells...Ch. 41 - Prob. 2.2A
Ch. 41 - Prob. 2.3ACh. 41 - Prob. 2.4ACh. 41 - Complete the following statements: A mature red...Ch. 41 - Prob. 2.6ACh. 41 - Prob. 2.7ACh. 41 - Prob. 2.8ACh. 41 - Prob. 2.9ACh. 41 - Prob. 2.10ACh. 41 - Complete the following statements: White blood...Ch. 41 - Prob. 2.12ACh. 41 - Prob. 2.13ACh. 41 - Prob. 2.14ACh. 41 - Complete the following statements: Small cell...Ch. 41 - Identify the blood cells indicated in figure 41.7...Ch. 41 - Which leukocyte type would likely be elevated in a...
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