Prescott's Microbiology
10th Edition
ISBN: 9781259281594
Author: Joanne Willey, Linda Sherwood Adjunt Professor Lecturer, Christopher J. Woolverton Professor
Publisher: McGraw-Hill Education
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Chapter 40, Problem 4CHI
The initial, nonsymptomatic liver stage (LS) of Plasmodium spp. is considered very promising for prophylactic drug and vaccine development (figure 40.9). However, technical obstacles in obtaining LS protists has hindered analysis of gene and protein expression. Tarun and her colleagues developed a rodent model whereby LS protists could be studied. They identified a set of proteins expressed only in the LS, including enzymes involved in
Examine the P. vivax life cycle in figure 40.7. Why do you think the metabolic requirements of LS protists are so unique? Having identified these proteins, what would be the next step in identifying drugs that might be effective against LS protozoa? How might this information assist in vaccine development?
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Chapter 40 Solutions
Prescott's Microbiology
Ch. 40.2 - What is the morphology of B. dermatitidis in the...Ch. 40.2 - Prob. 2MICh. 40.3 - How is a schizont formed? What is the cell type...Ch. 40.3 - What is currently the most effective strategy to...Ch. 40.3 - What is the primary reservoir of leishmanias? What...Ch. 40.3 - Prob. 1RIACh. 40.3 - Prob. 2RIACh. 40.3 - Why is Histoplasma capsulatum found in bird feces...Ch. 40.3 - What flagellated protists invade the blood? What...Ch. 40.3 - Describe the malarial life cycle. What stages of...
Ch. 40.3 - What malarial stages could vaccines block? What...Ch. 40.4 - Prob. 1MICh. 40.4 - How do fungi causing subcutaneous mycoses gain...Ch. 40.4 - Describe two piedras that infect humans.Ch. 40.4 - Briefly describe the major tineas that occur in...Ch. 40.4 - Prob. 3RIACh. 40.4 - How would you diagnose trichomoniasis in a female?...Ch. 40.5 - Upon entry into the human host by the nose or...Ch. 40.6 - How do infections caused by Entamoeba histolytica...Ch. 40.6 - What is the most common cause of epidemic...Ch. 40.6 - In what two ways does Toxoplasma affect human...Ch. 40.6 - Prob. 4RIACh. 40.6 - What parts of the human body can be affected by...Ch. 40.6 - Prob. 6RIACh. 40.6 - When is Pneumocystis pneumonia likely to occur in...Ch. 40 - What is one distinct feature of fungi that could...Ch. 40 - Prob. 2CHICh. 40 - Trypanosomes are notorious for their ability to...Ch. 40 - The initial, nonsymptomatic liver stage (LS) of...Ch. 40 - Prob. 5CHI
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