CAMPBELL BIOLOGY IN FOCUS-TEXT,AP ED.
3rd Edition
ISBN: 9780136811206
Author: Urry
Publisher: SAVVAS L
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Chapter 39.5, Problem 2CC
MAKE CONNECTIONS Balancing selection can maintain variation at a locus (see Concept 21.4). Based on the foraging experiments described in this chapter, devise a simple hypothesis to explain the presence of both forR and forS alleles in natural fly populations.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 39 Solutions
CAMPBELL BIOLOGY IN FOCUS-TEXT,AP ED.
Ch. 39.1 - Contrast the role of Ca2+ in the contraction of a...Ch. 39.1 - WHAT IF? Why are the muscles of an animal that has...Ch. 39.1 - Prob. 3CCCh. 39.2 - Prob. 1CCCh. 39.2 - Prob. 2CCCh. 39.2 - Prob. 3CCCh. 39.3 - Prob. 1CCCh. 39.3 - MAKE CONNECTIONS How is the lunar-linked rhythm of...Ch. 39.4 - How might associative learning explain why...Ch. 39.4 - Prob. 2CC
Ch. 39.4 - MAKE CONNECTIONS How might a learned behavior...Ch. 39.5 - Prob. 1CCCh. 39.5 - MAKE CONNECTIONS Balancing selection can maintain...Ch. 39.6 - Prob. 1CCCh. 39.6 - Prob. 2CCCh. 39 - During the contraction of a vertebrate skeletal...Ch. 39 - Prob. 2TYUCh. 39 - According to Hamiltons rule, A. natural selection...Ch. 39 - The binding of calcium to the troponin complex A....Ch. 39 - Curare, a substance that blocks the acetylcholine...Ch. 39 - Prob. 6TYUCh. 39 - Prob. 7TYUCh. 39 - SCIENTIFIC INQUIRY Propose a hypothesis to explain...Ch. 39 - Prob. 9TYUCh. 39 - Prob. 10TYUCh. 39 - FOCUS ON INFORMATION Learning is defined as a...Ch. 39 - Prob. 12TYU
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