Biology (MindTap Course List)
10th Edition
ISBN: 9781285423586
Author: Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
Publisher: Cengage Learning
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Textbook Question
Chapter 35, Problem 7TYU
Water potential is (a) the formation of a proton gradient across a cell membrane (b) the transport of a watery solution of sugar in phloem (c) the transport of water in both xylem and phloem (d) the removal of sucrose at the sink, causing water to move out of the sieve tubes (e) the free energy of water in a particular situation
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 35 Solutions
Biology (MindTap Course List)
Ch. 35.1 - Prob. 1LOCh. 35.1 - Prob. 2LOCh. 35.1 - Prob. 3LOCh. 35.1 - Prob. 1CCh. 35.1 - Prob. 2CCh. 35.1 - Prob. 3CCh. 35.1 - Prob. 4CCh. 35.1 - What is the difference between terminal and...Ch. 35.2 - Prob. 4LOCh. 35.2 - Prob. 5LO
Ch. 35.2 - Prob. 6LOCh. 35.2 - Prob. 1CCh. 35.2 - How does the tensioncohesion model explain the...Ch. 35.3 - Describe the pathway of sugar translocation in...Ch. 35.3 - Prob. 8LOCh. 35.3 - Prob. 1CCh. 35.3 - Prob. 2CCh. 35 - Prob. 1TYUCh. 35 - Ground tissue in monocot stems performs the same...Ch. 35 - Prob. 3TYUCh. 35 - Prob. 4TYUCh. 35 - Prob. 5TYUCh. 35 - Prob. 6TYUCh. 35 - Water potential is (a) the formation of a proton...Ch. 35 - Prob. 8TYUCh. 35 - Prob. 9TYUCh. 35 - Which of the following is a mechanism of phloem...Ch. 35 - How does increasing solute concentration affect...Ch. 35 - Prob. 12TYUCh. 35 - Prob. 13TYUCh. 35 - Prob. 14TYUCh. 35 - EVOLUTION LINK Like stems in general, some vines...Ch. 35 - Prob. 16TYU
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