Biological Science, Books a la Carte Plus Mastering Biology with Pearson eText -- Access Card Package (6th Edition)
Biological Science, Books a la Carte Plus Mastering Biology with Pearson eText -- Access Card Package (6th Edition)
6th Edition
ISBN: 9780134296029
Author: Scott Freeman, Kim Quillin, Lizabeth Allison, Michael Black, Greg Podgorski, Emily Taylor, Jeff Carmichael
Publisher: PEARSON
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Chapter 33, Problem 14PIAT
Summary Introduction

To review:

The results provided and conclusion about the early events of the Ebola virus infection.

Introduction:

Ebola virus can lead to severe and fatal hemorrhagic fever in human beings. The disease caused is known as Ebola virus disease. The reptilian host cells are able to take up the Ebola virus through the endocytosis process. However, the virus is unable to complete the uncoating step that is needed for the infection. The host cell was modified by incorporating a human protein called NPC1 that stays in the endosomal membrane. The graph and results were observed in the cells with and without the inhibitor.

Biological Science, Books a la Carte Plus Mastering Biology with Pearson eText -- Access Card Package (6th Edition), Chapter 33, Problem 14PIAT

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calculate the questions showing the solution including variables,unit and equations all the questiosn below using the data a) B1,   b) B2,   c) hybrid rate constant (1) d) hybrid rate constant (2) e) t1/2,dist f) t1/2,elim   g) k10 h) k12 i) k21 j) initial concentration (C0)   k) central compartment volume (V1) l) steady-state volume (Vss)   m) clearance (CL)  AUC (0→10 min) using trapezoidal rule n)  AUC (20→30 min) using trapezoidal rule o) AUCtail (AUC360→∞)   p) total AUC (using short cut method) q) volume from AUC (VAUC)
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