Explanation The BRCA2 gene is present on chromosome 13. The other DNA repair gene is present in its mutated form which is comparatively more capable of inheriting cancers of breast and ovary. In BRCA1 as well as BRCA2, both copies of the genes [homozygous state] must be inactivated for the development of the breast cancer...

Study Guide with Student Solutions Manual and Problems Book for Garrett/Grisham's Biochemistry, 6th

6th Edition

ISBN: 9798214167343

Author: GARRETT

Publisher: Cengage Learning US

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Question

Chapter 32, Problem 21P

Interpretation Introduction

Interpretation:

The mutation in the BRC motif that causes breast cancer needs to be discussed.

Concept Introduction :

Specific hereditary mutations within BRCA1 and BRCA2 particularly increases the chance of female ovarian and breast cancers, but they have also associated with increased risk of various additional types of cancer. The BRCA1and BRCA2 mutations might be genetic in nature.

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Chapter 32, Problem 20P

Chapter 32, Problem 22P

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Draw the predominant form of glutamic acid at pH = 8.4. The pKa of the side chain is 4.1. Include proper stereochemistry. HO H2N OH pH = 8.4

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Chapter 32 Solutions

Study Guide with Student Solutions Manual and Problems Book for Garrett/Grisham's Biochemistry, 6th

Ch. 32 - Prob. 1P Ch. 32 - Prob. 2P Ch. 32 - Prob. 3P Ch. 32 - Prob. 4P Ch. 32 - Prob. 5P Ch. 32 - Prob. 6P Ch. 32 - Prob. 7P Ch. 32 - Prob. 8P Ch. 32 - Prob. 9P Ch. 32 - Prob. 10P

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Solution Summary: The author explains that the mutation in the BRC motif that causes breast cancer needs to be discussed.

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