CAMP.BIO:CONC...MOD.MAST+PRINT>I<
CAMP.BIO:CONC...MOD.MAST+PRINT>I<
10th Edition
ISBN: 9780136858287
Author: Taylor
Publisher: INTER PEAR
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Chapter 30, Problem 18TYK

When a person dies, muscles become rigid and fixed in position—a condition known as rigor. Rigor mortis occurs because muscle cells are no longer supplied with ATP (when breathing stops, ATP synthesis ceases). Calcium also flows freely into dying cells. The rigor eventually disappears because the biological molecules break down. Explain, in terms of the mechanism of contraction described in Modules 30.9 and 30.10, why the presence of calcium and the lack of ATP would cause muscles to become rigid, rather than limp, soon after death.

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For a skeletal muscle to remain rigidly contracted, it needs a continual supply of ATP. Yet, when a skeletal muscle runs out of ATP (in a corpse), it becomes rigid. How can you explain this seeming paradox? Explain how skeletal muscle may remain relaxed even if ATP levels are high.
A few hours after the death of an animal, the corpse will stiffen as a result of continued contraction of muscle tissue (this state is called rigor mortis). This phenomenon is the result of the loss of ATP production in muscle tissue. (a) Consult Figure 7.48 and describe, in terms of the six-step model of mus- de contraction, how a lack of ATP in sarcomeres would result in rigor mortis. (b) The Ca* transporter in sarcomeres that keeps the [Ca*)-10-7 M requires ATP to drive transport of Ca* ions across the membrane of the sarcoplasmic reticulum. How would a loss of this Ca* transport func- tion result in the initiation of rigor mortis? (c) Rigor mortis is maximal at - 12 hrs after death, and by 72 hrs is no longer observed. Propose an explanation for the disappearance of rigor mortis after 12 hrs.
Shortly after a person dies, Calcium ions diffuse out of the sarcoplasmic reticulum and the body becomes very stiff and rigid, a phenomenon called rigor mortis (stiffness + death). Given ATP’s role in myosin head movement, propose an explanation for rigor mortis.
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