Concept explainers
To review:
The use of growing genetic understanding that shows the link between the fungal and animal genome, to develop the new antifungal drugs. And the name of antifungal drugs that exploit the biochemical differences between animals and fungai.
Introduction:
Phylogenetic relationship between the plants, animals and
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Biology: The Dynamic Science (MindTap Course List)
- In 1971, Dr. Akira Endo, working at the Sankyo company in Tokyo speculated that fungi not only contained antibiotics but also inhibitors of other processes such as cholesterol metabolism. Over a period of several years, he screened more than 6,000 fungal cultures until a positive result emerged. This compound, which was named compactin, came from the blue-green mold Penicillium citrinum Pen-5 that was isolated from a rice sample collected at a grain shop in Kyoto. Based on biochemical assays, compactin is the first known statin. 1. The original kinetics data for compactin inhibition of HMG-CoA reductase enzyme that was published by Dr. Endo in 1976 is shown on the right. a) Determine the Km and Vmax values for enzymatic activity. Do NOT forget the units. Answers can be expressed either as a fraction or in decimals. With No inhibitor: ; Vmax= -60 1/V, (nanomoles/min)-1 0.4 0.35+ 0.3 0.25 0.2 0.15 0.1 0.05 -40 -20 0 + 24 nM compactin + 70 nM compactin None T 20 40 60 1/[HMG-CoA], (mM)-1…arrow_forwardWhich of the following is a parasitic fungi on the mustardplant ?(a) Albugo (b) Puccinia(c) Yeast (d) Ustilago Please try to break the solutions into as many steps as practically possible and the steps should come one by one and they should be short and crisp and plagiarism-free.arrow_forwardAfter a long excursion in the tropics you came back with multiple soil samples from different localities across the Andes. You are interested in discovering new sources of pharmaceuticals and want to test the antibiotic properties of fungi collected from tropical soils at different altitudes. How would you approach this question?. What scientific experiment would you conduct to isolate fungi with antibiotic characteristics?. Please be specific about your design, including your expected outcomes and conclusions from your experiment.arrow_forward
- Health professionals refer to fungal skin diseases as "“tineas" and name them according to the region affected. Fungal skin diseases are persistent, in part, because fungi can penetrate deeper layers of skin than can ointments and creams. There are fewer antifungal drugs than ones, and antifungals often have more severe side effects. Reflect on the evolutionary relationships among bacteria, fungi, and humans. 1. List 5 different "Tineas" to show the connection between the name and the body parts affected from them. 2. Are fungi unicellular or multicellular organism? 3. Why it is harder to fight fungi than bacteria? 4. Why antifungals have more severe side effects?arrow_forwardWhile working in a plant disease diagnostic lab, you receive a sample of a very dead tomato plant. The plant has rotted roots and the symptoms match known fungal and oomycete diseases of tomatoes. Explain one difference between true fungi and oomycetes that you could observe to determine what type of organism is killing the tomatoes?arrow_forwardHow can we use fungi in biotechnology to save our World or decrease pollution? Give an example and explain research studies for your example.arrow_forward
- Please answer the following question. The use of DNA sequences resulted in a large number of novel fungi discovered. Explain how this was possible.arrow_forwardLook up the pH of lemon juice and vinegar. Based on your results and your knowledge of favorable environmental conditions for fungal growth, what can you conarrow_forwardWorldwide, frog populations are in decline. Several different fungi have been implicated in (thought to be the cause of) decreases in frog numbers. In particular, shrub frogs are especially at risk. You test several different fungi species to see how they affect sample populations of splotched frogs, a close relative of the shrub frog that is not endangered. To do this, you use the different species of fungi to infect populations of splotched frogs and then measure survival rates of these frogs at different frog densities. Frog densities are given in column 1 of the table below. The frog population in column 2 is the control, which was not infected with a fungus. Initial density of frog population (before introduction of Frog survival Frog survival Frog survival Frog survival Frog survival rate rate rate rate rate Control Fungus Fungus Fungus B. grenchius Fungus B. sporifera B. noeltid B. talbuta fungus) Per 1000 m2 10 0.95 0.72 0.83 0.90 0.5 50 0.9 0.64 0.82 0.87 0.35 75 0.88 0.66…arrow_forward
- Fungi tend to reproduce sexually when nutrients are limited or other conditions are unfavorable, but they reproduce asexually in more ideal conditions. Why is this strategy successful? Need referencearrow_forwardDiscuss the economic importance of imperfect fungi.arrow_forwardThe fungi in the photograph seem to be different individuals, can their DNA be identical? Explain.arrow_forward
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