The polypeptide that is more soluble at pH 7 in between ( Gly ) 20 and ( Glu ) 20 . Introduction: Solubility of a polypeptide is its property to dissolve in another substance that depends on its physical and chemical properties. Solubility of polypeptides depends on the polarity of side chains and number of ionized groups.

Question

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Answer 1

Question

Definition Definition Chemical process in which one or more monomers combine to produce a very large chain-like molecule called a polymer. The functional groups present on the monomers and their steric effects are responsible for polymerization through a sequence of reactions that vary in complexity. There exists a stable covalent chemical bond between monomers that sets apart polymerization from other processes.

Chapter 3, Problem 14P

(a)

Summary Introduction

To determine: The polypeptide that is more soluble at pH 7 in between (Gly)20 and (Glu)20.

Introduction: Solubility of a polypeptide is its property to dissolve in another substance that depends on its physical and chemical properties. Solubility of polypeptides depends on the polarity of side chains and number of ionized groups.

(a)

Expert Solution

Explanation of Solution

At pH=7.0, glutamate has more ionizable groups than that of glycine. Glycine belongs to neutral amino acid groups whereas the glutamine has high negative charge at the pH 7. The solubility of a polypeptide increases if more ionisable groups are present in it. This is the reason behind more solubility of (Glu)20 than (Gly)20 at pH=7.0.

Conclusion

The solubility of (Glu)20 would be more than (Gly)20 at pH=7.0.

(b)

Summary Introduction

To determine: The polypeptide that is more soluble at pH 7 in between (Lys−Ala)3 and (Phe−Met)3.

Introduction: Solubility of a polypeptide is its property to dissolve in another substance. Solubility of a substance depends on the physical and chemical properties of the substance. Solubility of polypeptides depends on the polarity of side chains and number of ionized groups.

(b)

Expert Solution

Explanation of Solution

(Lys−Ala)3 is a pair of polypeptide that consists of more ionisable groups and have high positively charged groups than (Phe−Met)3. This is because of larger number of ionisable charged groups present on lysine side chain. (Phe−Met)3 is less polar than (Lys−Ala)3. So, (Lys−Ala)3 is more soluble than (Phe−Met)3 at pH=7.0.

Conclusion

(Lys−Ala)3 is more soluble than (Phe−Met)3 at pH=7.0.

(c)

Summary Introduction

To determine: The polypeptide that is more soluble at pH 6 in between (Ala-Ser-Gly)5 and (Asn−Ser−His)5.

Introduction: Solubility of a polypeptide is its property to dissolve in another substance. Solubility of a substance depends on the physical and chemical properties of the substance. Solubility of polypeptides depends on the polarity of side chains and number of ionized groups.

(c)

Expert Solution

Explanation of Solution

(Asn−Ser−His)5 polypeptides are more soluble than the (Ala-Ser-Gly)5 at pH=6.0. Both polypeptides have the serine side chains and are polymeric molecules. But additionally, (Asn−Ser−His)5 has polar group asparagine and also are partially protonated. Thus, (Asn−Ser−His)5 is more soluble than (Ala-Ser-Gly)5 at pH=6.0.

Conclusion

(Asn−Ser−His)5 is more soluble than (Ala-Ser-Gly)5 at pH=6.0.

(d)

Summary Introduction

To determine: The polypeptide that is more soluble at pH 3 in between (Ala-Asp-Gly)5 and (Asn−Ser−His)5.

Introduction: Solubility of a polypeptide is its property to dissolve in another substance. Solubility of a substance depends on the physical and chemical properties of the substance. Solubility of polypeptides depends on the polarity of side chains and number of ionized groups.

(d)

Expert Solution

Explanation of Solution

At pH=3.0, (Asn−Ser−His)5 shows more solubility than (Ala-Asp-Gly)5. The imidazole groups of the His residues present in the (Asn−Ser−His)5 polypeptide are positively charged and fully protonated. Whereas the carboxylate groups of the Asp residues are neutral and partially protonated. This is because (Asn−Ser−His)5 are more soluble at pH=3.0.

Conclusion

(Asn−Ser−His)5 is more soluble than (Ala-Asp-Gly)5 at pH=3.0.

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The two half reactions for beginning and end of the electron transport chain are given below in standard form. Calculate & for the overall process. Using the Nernst equation (AG° = -n Fo, F= 96.485 kJ/volt mol), calculate AG°. Explain the need for a stepwise process in the electron transport chain. NAD* + H+ + 2 e- = NADH ½ 0г + 2H+ + 2е- = H20 = -0.32v E = +0.82V

Answer 2

Question

Definition Definition Chemical process in which one or more monomers combine to produce a very large chain-like molecule called a polymer. The functional groups present on the monomers and their steric effects are responsible for polymerization through a sequence of reactions that vary in complexity. There exists a stable covalent chemical bond between monomers that sets apart polymerization from other processes.

Chapter 3, Problem 14P

(a)

Summary Introduction

To determine: The polypeptide that is more soluble at pH 7 in between (Gly)20 and (Glu)20.

Introduction: Solubility of a polypeptide is its property to dissolve in another substance that depends on its physical and chemical properties. Solubility of polypeptides depends on the polarity of side chains and number of ionized groups.

(a)

Expert Solution

Explanation of Solution

At pH=7.0, glutamate has more ionizable groups than that of glycine. Glycine belongs to neutral amino acid groups whereas the glutamine has high negative charge at the pH 7. The solubility of a polypeptide increases if more ionisable groups are present in it. This is the reason behind more solubility of (Glu)20 than (Gly)20 at pH=7.0.

Conclusion

The solubility of (Glu)20 would be more than (Gly)20 at pH=7.0.

(b)

Summary Introduction

To determine: The polypeptide that is more soluble at pH 7 in between (Lys−Ala)3 and (Phe−Met)3.

Introduction: Solubility of a polypeptide is its property to dissolve in another substance. Solubility of a substance depends on the physical and chemical properties of the substance. Solubility of polypeptides depends on the polarity of side chains and number of ionized groups.

(b)

Expert Solution

Explanation of Solution

(Lys−Ala)3 is a pair of polypeptide that consists of more ionisable groups and have high positively charged groups than (Phe−Met)3. This is because of larger number of ionisable charged groups present on lysine side chain. (Phe−Met)3 is less polar than (Lys−Ala)3. So, (Lys−Ala)3 is more soluble than (Phe−Met)3 at pH=7.0.

Conclusion

(Lys−Ala)3 is more soluble than (Phe−Met)3 at pH=7.0.

(c)

Summary Introduction

To determine: The polypeptide that is more soluble at pH 6 in between (Ala-Ser-Gly)5 and (Asn−Ser−His)5.

Introduction: Solubility of a polypeptide is its property to dissolve in another substance. Solubility of a substance depends on the physical and chemical properties of the substance. Solubility of polypeptides depends on the polarity of side chains and number of ionized groups.

(c)

Expert Solution

Explanation of Solution

(Asn−Ser−His)5 polypeptides are more soluble than the (Ala-Ser-Gly)5 at pH=6.0. Both polypeptides have the serine side chains and are polymeric molecules. But additionally, (Asn−Ser−His)5 has polar group asparagine and also are partially protonated. Thus, (Asn−Ser−His)5 is more soluble than (Ala-Ser-Gly)5 at pH=6.0.

Conclusion

(Asn−Ser−His)5 is more soluble than (Ala-Ser-Gly)5 at pH=6.0.

(d)

Summary Introduction

To determine: The polypeptide that is more soluble at pH 3 in between (Ala-Asp-Gly)5 and (Asn−Ser−His)5.

Introduction: Solubility of a polypeptide is its property to dissolve in another substance. Solubility of a substance depends on the physical and chemical properties of the substance. Solubility of polypeptides depends on the polarity of side chains and number of ionized groups.

(d)

Expert Solution

Explanation of Solution

At pH=3.0, (Asn−Ser−His)5 shows more solubility than (Ala-Asp-Gly)5. The imidazole groups of the His residues present in the (Asn−Ser−His)5 polypeptide are positively charged and fully protonated. Whereas the carboxylate groups of the Asp residues are neutral and partially protonated. This is because (Asn−Ser−His)5 are more soluble at pH=3.0.

Conclusion

(Asn−Ser−His)5 is more soluble than (Ala-Asp-Gly)5 at pH=3.0.

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Answer 3

Question

Definition Definition Chemical process in which one or more monomers combine to produce a very large chain-like molecule called a polymer. The functional groups present on the monomers and their steric effects are responsible for polymerization through a sequence of reactions that vary in complexity. There exists a stable covalent chemical bond between monomers that sets apart polymerization from other processes.

Chapter 3, Problem 14P

(a)

Summary Introduction

To determine: The polypeptide that is more soluble at pH 7 in between (Gly)20 and (Glu)20.

Introduction: Solubility of a polypeptide is its property to dissolve in another substance that depends on its physical and chemical properties. Solubility of polypeptides depends on the polarity of side chains and number of ionized groups.

(a)

Expert Solution

Explanation of Solution

At pH=7.0, glutamate has more ionizable groups than that of glycine. Glycine belongs to neutral amino acid groups whereas the glutamine has high negative charge at the pH 7. The solubility of a polypeptide increases if more ionisable groups are present in it. This is the reason behind more solubility of (Glu)20 than (Gly)20 at pH=7.0.

Conclusion

The solubility of (Glu)20 would be more than (Gly)20 at pH=7.0.

(b)

Summary Introduction

To determine: The polypeptide that is more soluble at pH 7 in between (Lys−Ala)3 and (Phe−Met)3.

Introduction: Solubility of a polypeptide is its property to dissolve in another substance. Solubility of a substance depends on the physical and chemical properties of the substance. Solubility of polypeptides depends on the polarity of side chains and number of ionized groups.

(b)

Expert Solution

Explanation of Solution

(Lys−Ala)3 is a pair of polypeptide that consists of more ionisable groups and have high positively charged groups than (Phe−Met)3. This is because of larger number of ionisable charged groups present on lysine side chain. (Phe−Met)3 is less polar than (Lys−Ala)3. So, (Lys−Ala)3 is more soluble than (Phe−Met)3 at pH=7.0.

Conclusion

(Lys−Ala)3 is more soluble than (Phe−Met)3 at pH=7.0.

(c)

Summary Introduction

To determine: The polypeptide that is more soluble at pH 6 in between (Ala-Ser-Gly)5 and (Asn−Ser−His)5.

Introduction: Solubility of a polypeptide is its property to dissolve in another substance. Solubility of a substance depends on the physical and chemical properties of the substance. Solubility of polypeptides depends on the polarity of side chains and number of ionized groups.

(c)

Expert Solution

Explanation of Solution

(Asn−Ser−His)5 polypeptides are more soluble than the (Ala-Ser-Gly)5 at pH=6.0. Both polypeptides have the serine side chains and are polymeric molecules. But additionally, (Asn−Ser−His)5 has polar group asparagine and also are partially protonated. Thus, (Asn−Ser−His)5 is more soluble than (Ala-Ser-Gly)5 at pH=6.0.

Conclusion

(Asn−Ser−His)5 is more soluble than (Ala-Ser-Gly)5 at pH=6.0.

(d)

Summary Introduction

To determine: The polypeptide that is more soluble at pH 3 in between (Ala-Asp-Gly)5 and (Asn−Ser−His)5.

Introduction: Solubility of a polypeptide is its property to dissolve in another substance. Solubility of a substance depends on the physical and chemical properties of the substance. Solubility of polypeptides depends on the polarity of side chains and number of ionized groups.

(d)

Expert Solution

Explanation of Solution

At pH=3.0, (Asn−Ser−His)5 shows more solubility than (Ala-Asp-Gly)5. The imidazole groups of the His residues present in the (Asn−Ser−His)5 polypeptide are positively charged and fully protonated. Whereas the carboxylate groups of the Asp residues are neutral and partially protonated. This is because (Asn−Ser−His)5 are more soluble at pH=3.0.

Conclusion

(Asn−Ser−His)5 is more soluble than (Ala-Asp-Gly)5 at pH=3.0.

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Answer 4

Question

Definition Definition Chemical process in which one or more monomers combine to produce a very large chain-like molecule called a polymer. The functional groups present on the monomers and their steric effects are responsible for polymerization through a sequence of reactions that vary in complexity. There exists a stable covalent chemical bond between monomers that sets apart polymerization from other processes.

Chapter 3, Problem 14P

(a)

Summary Introduction

To determine: The polypeptide that is more soluble at pH 7 in between (Gly)20 and (Glu)20.

Introduction: Solubility of a polypeptide is its property to dissolve in another substance that depends on its physical and chemical properties. Solubility of polypeptides depends on the polarity of side chains and number of ionized groups.

(a)

Expert Solution

Explanation of Solution

At pH=7.0, glutamate has more ionizable groups than that of glycine. Glycine belongs to neutral amino acid groups whereas the glutamine has high negative charge at the pH 7. The solubility of a polypeptide increases if more ionisable groups are present in it. This is the reason behind more solubility of (Glu)20 than (Gly)20 at pH=7.0.

Conclusion

The solubility of (Glu)20 would be more than (Gly)20 at pH=7.0.

(b)

Summary Introduction

To determine: The polypeptide that is more soluble at pH 7 in between (Lys−Ala)3 and (Phe−Met)3.

Introduction: Solubility of a polypeptide is its property to dissolve in another substance. Solubility of a substance depends on the physical and chemical properties of the substance. Solubility of polypeptides depends on the polarity of side chains and number of ionized groups.

(b)

Expert Solution

Explanation of Solution

(Lys−Ala)3 is a pair of polypeptide that consists of more ionisable groups and have high positively charged groups than (Phe−Met)3. This is because of larger number of ionisable charged groups present on lysine side chain. (Phe−Met)3 is less polar than (Lys−Ala)3. So, (Lys−Ala)3 is more soluble than (Phe−Met)3 at pH=7.0.

Conclusion

(Lys−Ala)3 is more soluble than (Phe−Met)3 at pH=7.0.

(c)

Summary Introduction

To determine: The polypeptide that is more soluble at pH 6 in between (Ala-Ser-Gly)5 and (Asn−Ser−His)5.

Introduction: Solubility of a polypeptide is its property to dissolve in another substance. Solubility of a substance depends on the physical and chemical properties of the substance. Solubility of polypeptides depends on the polarity of side chains and number of ionized groups.

(c)

Expert Solution

Explanation of Solution

(Asn−Ser−His)5 polypeptides are more soluble than the (Ala-Ser-Gly)5 at pH=6.0. Both polypeptides have the serine side chains and are polymeric molecules. But additionally, (Asn−Ser−His)5 has polar group asparagine and also are partially protonated. Thus, (Asn−Ser−His)5 is more soluble than (Ala-Ser-Gly)5 at pH=6.0.

Conclusion

(Asn−Ser−His)5 is more soluble than (Ala-Ser-Gly)5 at pH=6.0.

(d)

Summary Introduction

To determine: The polypeptide that is more soluble at pH 3 in between (Ala-Asp-Gly)5 and (Asn−Ser−His)5.

Introduction: Solubility of a polypeptide is its property to dissolve in another substance. Solubility of a substance depends on the physical and chemical properties of the substance. Solubility of polypeptides depends on the polarity of side chains and number of ionized groups.

(d)

Expert Solution

Explanation of Solution

At pH=3.0, (Asn−Ser−His)5 shows more solubility than (Ala-Asp-Gly)5. The imidazole groups of the His residues present in the (Asn−Ser−His)5 polypeptide are positively charged and fully protonated. Whereas the carboxylate groups of the Asp residues are neutral and partially protonated. This is because (Asn−Ser−His)5 are more soluble at pH=3.0.

Conclusion

(Asn−Ser−His)5 is more soluble than (Ala-Asp-Gly)5 at pH=3.0.

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Answer 5

Chapter 3, Problem 14P

(a)

Summary Introduction

To determine: The polypeptide that is more soluble at pH 7 in between (Gly)20 and (Glu)20.

Introduction: Solubility of a polypeptide is its property to dissolve in another substance that depends on its physical and chemical properties. Solubility of polypeptides depends on the polarity of side chains and number of ionized groups.

(a)

Expert Solution

Explanation of Solution

At pH=7.0, glutamate has more ionizable groups than that of glycine. Glycine belongs to neutral amino acid groups whereas the glutamine has high negative charge at the pH 7. The solubility of a polypeptide increases if more ionisable groups are present in it. This is the reason behind more solubility of (Glu)20 than (Gly)20 at pH=7.0.

Conclusion

The solubility of (Glu)20 would be more than (Gly)20 at pH=7.0.

(b)

Summary Introduction

To determine: The polypeptide that is more soluble at pH 7 in between (Lys−Ala)3 and (Phe−Met)3.

Introduction: Solubility of a polypeptide is its property to dissolve in another substance. Solubility of a substance depends on the physical and chemical properties of the substance. Solubility of polypeptides depends on the polarity of side chains and number of ionized groups.

(b)

Expert Solution

Explanation of Solution

(Lys−Ala)3 is a pair of polypeptide that consists of more ionisable groups and have high positively charged groups than (Phe−Met)3. This is because of larger number of ionisable charged groups present on lysine side chain. (Phe−Met)3 is less polar than (Lys−Ala)3. So, (Lys−Ala)3 is more soluble than (Phe−Met)3 at pH=7.0.

Conclusion

(Lys−Ala)3 is more soluble than (Phe−Met)3 at pH=7.0.

(c)

Summary Introduction

To determine: The polypeptide that is more soluble at pH 6 in between (Ala-Ser-Gly)5 and (Asn−Ser−His)5.

Introduction: Solubility of a polypeptide is its property to dissolve in another substance. Solubility of a substance depends on the physical and chemical properties of the substance. Solubility of polypeptides depends on the polarity of side chains and number of ionized groups.

(c)

Expert Solution

Explanation of Solution

(Asn−Ser−His)5 polypeptides are more soluble than the (Ala-Ser-Gly)5 at pH=6.0. Both polypeptides have the serine side chains and are polymeric molecules. But additionally, (Asn−Ser−His)5 has polar group asparagine and also are partially protonated. Thus, (Asn−Ser−His)5 is more soluble than (Ala-Ser-Gly)5 at pH=6.0.

Conclusion

(Asn−Ser−His)5 is more soluble than (Ala-Ser-Gly)5 at pH=6.0.

(d)

Summary Introduction

To determine: The polypeptide that is more soluble at pH 3 in between (Ala-Asp-Gly)5 and (Asn−Ser−His)5.

Introduction: Solubility of a polypeptide is its property to dissolve in another substance. Solubility of a substance depends on the physical and chemical properties of the substance. Solubility of polypeptides depends on the polarity of side chains and number of ionized groups.

(d)

Expert Solution

Explanation of Solution

At pH=3.0, (Asn−Ser−His)5 shows more solubility than (Ala-Asp-Gly)5. The imidazole groups of the His residues present in the (Asn−Ser−His)5 polypeptide are positively charged and fully protonated. Whereas the carboxylate groups of the Asp residues are neutral and partially protonated. This is because (Asn−Ser−His)5 are more soluble at pH=3.0.

Conclusion

(Asn−Ser−His)5 is more soluble than (Ala-Asp-Gly)5 at pH=3.0.

Answer 6

Chapter 3, Problem 14P

(a)

Summary Introduction

To determine: The polypeptide that is more soluble at pH 7 in between (Gly)20 and (Glu)20.

Introduction: Solubility of a polypeptide is its property to dissolve in another substance that depends on its physical and chemical properties. Solubility of polypeptides depends on the polarity of side chains and number of ionized groups.

(a)

Expert Solution

Explanation of Solution

At pH=7.0, glutamate has more ionizable groups than that of glycine. Glycine belongs to neutral amino acid groups whereas the glutamine has high negative charge at the pH 7. The solubility of a polypeptide increases if more ionisable groups are present in it. This is the reason behind more solubility of (Glu)20 than (Gly)20 at pH=7.0.

Conclusion

The solubility of (Glu)20 would be more than (Gly)20 at pH=7.0.

Answer 7

Chapter 3, Problem 14P

(a)

Summary Introduction

To determine: The polypeptide that is more soluble at pH 7 in between (Gly)20 and (Glu)20.

Introduction: Solubility of a polypeptide is its property to dissolve in another substance that depends on its physical and chemical properties. Solubility of polypeptides depends on the polarity of side chains and number of ionized groups.

Answer 8

(a)

Expert Solution

Explanation of Solution

At pH=7.0, glutamate has more ionizable groups than that of glycine. Glycine belongs to neutral amino acid groups whereas the glutamine has high negative charge at the pH 7. The solubility of a polypeptide increases if more ionisable groups are present in it. This is the reason behind more solubility of (Glu)20 than (Gly)20 at pH=7.0.

Answer 9

(a)

Expert Solution

Answer 10

(a)

Expert Solution

Answer 11

Expert Solution

Answer 12

Conclusion

The solubility of (Glu)20 would be more than (Gly)20 at pH=7.0.

Answer 13

(b)

Summary Introduction

To determine: The polypeptide that is more soluble at pH 7 in between (Lys−Ala)3 and (Phe−Met)3.

Introduction: Solubility of a polypeptide is its property to dissolve in another substance. Solubility of a substance depends on the physical and chemical properties of the substance. Solubility of polypeptides depends on the polarity of side chains and number of ionized groups.

(b)

Expert Solution

Explanation of Solution

(Lys−Ala)3 is a pair of polypeptide that consists of more ionisable groups and have high positively charged groups than (Phe−Met)3. This is because of larger number of ionisable charged groups present on lysine side chain. (Phe−Met)3 is less polar than (Lys−Ala)3. So, (Lys−Ala)3 is more soluble than (Phe−Met)3 at pH=7.0.

Conclusion

(Lys−Ala)3 is more soluble than (Phe−Met)3 at pH=7.0.

Answer 14

(b)

Summary Introduction

To determine: The polypeptide that is more soluble at pH 7 in between (Lys−Ala)3 and (Phe−Met)3.

Introduction: Solubility of a polypeptide is its property to dissolve in another substance. Solubility of a substance depends on the physical and chemical properties of the substance. Solubility of polypeptides depends on the polarity of side chains and number of ionized groups.

Answer 15

(b)

Expert Solution

Explanation of Solution

(Lys−Ala)3 is a pair of polypeptide that consists of more ionisable groups and have high positively charged groups than (Phe−Met)3. This is because of larger number of ionisable charged groups present on lysine side chain. (Phe−Met)3 is less polar than (Lys−Ala)3. So, (Lys−Ala)3 is more soluble than (Phe−Met)3 at pH=7.0.

Answer 16

(b)

Expert Solution

Answer 17

(b)

Expert Solution

Answer 18

Expert Solution

Answer 19

Conclusion

(Lys−Ala)3 is more soluble than (Phe−Met)3 at pH=7.0.

Answer 20

(c)

Summary Introduction

To determine: The polypeptide that is more soluble at pH 6 in between (Ala-Ser-Gly)5 and (Asn−Ser−His)5.

Introduction: Solubility of a polypeptide is its property to dissolve in another substance. Solubility of a substance depends on the physical and chemical properties of the substance. Solubility of polypeptides depends on the polarity of side chains and number of ionized groups.

(c)

Expert Solution

Explanation of Solution

(Asn−Ser−His)5 polypeptides are more soluble than the (Ala-Ser-Gly)5 at pH=6.0. Both polypeptides have the serine side chains and are polymeric molecules. But additionally, (Asn−Ser−His)5 has polar group asparagine and also are partially protonated. Thus, (Asn−Ser−His)5 is more soluble than (Ala-Ser-Gly)5 at pH=6.0.

Conclusion

(Asn−Ser−His)5 is more soluble than (Ala-Ser-Gly)5 at pH=6.0.

Answer 21

(c)

Summary Introduction

To determine: The polypeptide that is more soluble at pH 6 in between (Ala-Ser-Gly)5 and (Asn−Ser−His)5.

Introduction: Solubility of a polypeptide is its property to dissolve in another substance. Solubility of a substance depends on the physical and chemical properties of the substance. Solubility of polypeptides depends on the polarity of side chains and number of ionized groups.

Answer 22

(c)

Expert Solution

Explanation of Solution

(Asn−Ser−His)5 polypeptides are more soluble than the (Ala-Ser-Gly)5 at pH=6.0. Both polypeptides have the serine side chains and are polymeric molecules. But additionally, (Asn−Ser−His)5 has polar group asparagine and also are partially protonated. Thus, (Asn−Ser−His)5 is more soluble than (Ala-Ser-Gly)5 at pH=6.0.

Answer 23

(c)

Expert Solution

Answer 24

(c)

Expert Solution

Answer 25

Expert Solution

Answer 26

Conclusion

(Asn−Ser−His)5 is more soluble than (Ala-Ser-Gly)5 at pH=6.0.

Answer 27

(d)

Summary Introduction

To determine: The polypeptide that is more soluble at pH 3 in between (Ala-Asp-Gly)5 and (Asn−Ser−His)5.

Introduction: Solubility of a polypeptide is its property to dissolve in another substance. Solubility of a substance depends on the physical and chemical properties of the substance. Solubility of polypeptides depends on the polarity of side chains and number of ionized groups.

(d)

Expert Solution

Explanation of Solution

At pH=3.0, (Asn−Ser−His)5 shows more solubility than (Ala-Asp-Gly)5. The imidazole groups of the His residues present in the (Asn−Ser−His)5 polypeptide are positively charged and fully protonated. Whereas the carboxylate groups of the Asp residues are neutral and partially protonated. This is because (Asn−Ser−His)5 are more soluble at pH=3.0.

Conclusion

(Asn−Ser−His)5 is more soluble than (Ala-Asp-Gly)5 at pH=3.0.

Answer 28

(d)

Summary Introduction

To determine: The polypeptide that is more soluble at pH 3 in between (Ala-Asp-Gly)5 and (Asn−Ser−His)5.

Introduction: Solubility of a polypeptide is its property to dissolve in another substance. Solubility of a substance depends on the physical and chemical properties of the substance. Solubility of polypeptides depends on the polarity of side chains and number of ionized groups.

Answer 29

(d)

Expert Solution

Explanation of Solution

At pH=3.0, (Asn−Ser−His)5 shows more solubility than (Ala-Asp-Gly)5. The imidazole groups of the His residues present in the (Asn−Ser−His)5 polypeptide are positively charged and fully protonated. Whereas the carboxylate groups of the Asp residues are neutral and partially protonated. This is because (Asn−Ser−His)5 are more soluble at pH=3.0.