Campbell Biology in Focus
Campbell Biology in Focus
3rd Edition
ISBN: 9780134710679
Author: Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Rebecca Orr
Publisher: PEARSON
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Chapter 3, Problem 11TYU
Summary Introduction

To explain:

What type of amino acids are present in the DNA-binding region of proteins.

Concept introduction:

DNA-binding proteins are a specific type of protein that contain DNA-binding domains. They possess a high affinity toward single or double-stranded DNA molecules. These DNA-binding proteins interact with DNA molecules at a major or minor groove of the DNA structure. These proteins help in modulating the function of DNA, for example, transcription.

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Suppose that the gene for a protein 500 amino acids in length undergoes a mutation. If the mutation causes the synthesis of a mutant protein in which just one of the 500 amino acids is incorrect, the protein may lose its biological function. How can a small change in a protein's sequence inactivate the protein? The catalytic site of the protein may be malformed, preventing complementary fit. RNA may not recognize the altered DNA sequence, and bases may pair incorrectly. It may alter the shape of the protein's molecular chaperone, preventing proper protein folding. The active site may base pair incorrectly with the complementary DNA strand. The resulting protein may fold incorrectly and may not attain its native conformation.
Consider the following DNA sequence:CATGTGTAGTCTAAAa. Write the sequence of the DNA strand that would be repli-cated from this one.b. Write the sequence of the RNA molecule that would betranscribed from the DNA strand.c. State how many codons the sequence specifies.d. State how many amino acids the sequence specifies
Models of real-world phenomena can reveal important links between structure and function in biology. Describe how the structure of DNA revealed by theWatson and Crick model suggests how it functions in living things.

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Campbell Biology in Focus

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