EBK CAMPBELL BIOLOGY
11th Edition
ISBN: 8220103613828
Author: Reece
Publisher: PEARSON
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Textbook Question
Chapter 29.1, Problem 3CC
WHAT IF? Ø What would the human life cycle be like if we had alternation of generations? Assume that the multicellular diploid stage would be similar in form to an adult human.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 29 Solutions
EBK CAMPBELL BIOLOGY
Ch. 29.1 - Why do researchers identify the charophytes rather...Ch. 29.1 - Identify four derived traits that distinguish...Ch. 29.1 - WHAT IF? What would the human life cycle be like...Ch. 29.2 - Prob. 1CCCh. 29.2 - Give three examples of how structure fits function...Ch. 29.2 - MAKE CONNECTIONS Review the discussion of...Ch. 29.3 - List the key derived traits found in monilophytes...Ch. 29.3 - Prob. 2CCCh. 29.3 - MAKE CONNECTIONS In Figure 29.12, if...Ch. 29 - Draw a phylogenetic tree illustrating our current...
Ch. 29 - Summarize the ecological importance of mosses.Ch. 29 - What trait(s) allowed vascular plants to grow...Ch. 29 - Three of the following are evidence that...Ch. 29 - Which of the following characteristics of plants...Ch. 29 - In plants, which of the following are produced by...Ch. 29 - Microphylls are found in which plant group? (A)...Ch. 29 - Suppose an efficient conducting system evolved in...Ch. 29 - Identify each of the following structures as...Ch. 29 - EVOLUTION CONNECTION DRAW IT Draw a phylogenetic...Ch. 29 - SCIENTIFIC INQUIRY INTERPRET THE DATA Ihe feather...Ch. 29 - WRITE ABOUT A THEME: INTERACTIONS Giant lycophyte...Ch. 29 - SYNTHESIZE YOUR KNOWLEDGE These stomata are from...
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